Abstract
Integrin-mediated adhesive interactions are viewed in the context of HIV transmission to susceptible cells and fertilization. The ability of a low- molecular-weight non-peptide integrin modulator to inhibit HIV infection (virus-to-cell and cell-to-cell) and sperm-egg fusion is demonstrated. It is concluded that integrin-modulating substances offer significant promise as female-controlled means for preventing sexual transmission of HIV (whatever entity acts as HIV vector in semen and other penile secretions) and as female-controlled contraceptives.
Original language | English (US) |
---|---|
Pages (from-to) | 271-290 |
Number of pages | 20 |
Journal | Journal of Reproductive Immunology |
Volume | 41 |
Issue number | 1-2 |
DOIs | |
State | Published - Nov 1 1998 |
Keywords
- CD4- independent HIV transmission
- Integrin-mediated adhesion
- Integrin-mediated fusion
- LFA-1
- Oocyte penetration
- VLA-4
ASJC Scopus subject areas
- Immunology
- Reproductive Medicine