Modulation of integrin function inhibits HIV transmission to epithelial cells and fertilization

John B. Davidson; Gordon C Douglas

doi:10.1016/S0165-0378(98)00064-3

Modulation of integrin function inhibits HIV transmission to epithelial cells and fertilization

John B. Davidson, Gordon C Douglas

Cell Biology and Human Anatomy

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Integrin-mediated adhesive interactions are viewed in the context of HIV transmission to susceptible cells and fertilization. The ability of a low- molecular-weight non-peptide integrin modulator to inhibit HIV infection (virus-to-cell and cell-to-cell) and sperm-egg fusion is demonstrated. It is concluded that integrin-modulating substances offer significant promise as female-controlled means for preventing sexual transmission of HIV (whatever entity acts as HIV vector in semen and other penile secretions) and as female-controlled contraceptives.

Original language	English (US)
Pages (from-to)	271-290
Number of pages	20
Journal	Journal of Reproductive Immunology
Volume	41
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-0378(98)00064-3
State	Published - Nov 1 1998

Keywords

CD4- independent HIV transmission
Integrin-mediated adhesion
Integrin-mediated fusion
LFA-1
Oocyte penetration
VLA-4

ASJC Scopus subject areas

Immunology
Reproductive Medicine

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abstract = "Integrin-mediated adhesive interactions are viewed in the context of HIV transmission to susceptible cells and fertilization. The ability of a low- molecular-weight non-peptide integrin modulator to inhibit HIV infection (virus-to-cell and cell-to-cell) and sperm-egg fusion is demonstrated. It is concluded that integrin-modulating substances offer significant promise as female-controlled means for preventing sexual transmission of HIV (whatever entity acts as HIV vector in semen and other penile secretions) and as female-controlled contraceptives.",

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AU - Douglas, Gordon C

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AB - Integrin-mediated adhesive interactions are viewed in the context of HIV transmission to susceptible cells and fertilization. The ability of a low- molecular-weight non-peptide integrin modulator to inhibit HIV infection (virus-to-cell and cell-to-cell) and sperm-egg fusion is demonstrated. It is concluded that integrin-modulating substances offer significant promise as female-controlled means for preventing sexual transmission of HIV (whatever entity acts as HIV vector in semen and other penile secretions) and as female-controlled contraceptives.

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KW - VLA-4

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