Modulation of integrin function inhibits HIV transmission to epithelial cells and fertilization

John B. Davidson, Gordon C Douglas

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Integrin-mediated adhesive interactions are viewed in the context of HIV transmission to susceptible cells and fertilization. The ability of a low- molecular-weight non-peptide integrin modulator to inhibit HIV infection (virus-to-cell and cell-to-cell) and sperm-egg fusion is demonstrated. It is concluded that integrin-modulating substances offer significant promise as female-controlled means for preventing sexual transmission of HIV (whatever entity acts as HIV vector in semen and other penile secretions) and as female-controlled contraceptives.

Original languageEnglish (US)
Pages (from-to)271-290
Number of pages20
JournalJournal of Reproductive Immunology
Volume41
Issue number1-2
DOIs
StatePublished - Nov 1 1998

    Fingerprint

Keywords

  • CD4- independent HIV transmission
  • Integrin-mediated adhesion
  • Integrin-mediated fusion
  • LFA-1
  • Oocyte penetration
  • VLA-4

ASJC Scopus subject areas

  • Immunology
  • Reproductive Medicine

Cite this