Modulation of integrin function inhibits HIV transmission to epithelial cells and fertilization

John B. Davidson; Gordon C Douglas

doi:10.1016/S0165-0378(98)00064-3

Modulation of integrin function inhibits HIV transmission to epithelial cells and fertilization

John B. Davidson, Gordon C Douglas

Cell Biology and Human Anatomy

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Integrin-mediated adhesive interactions are viewed in the context of HIV transmission to susceptible cells and fertilization. The ability of a low- molecular-weight non-peptide integrin modulator to inhibit HIV infection (virus-to-cell and cell-to-cell) and sperm-egg fusion is demonstrated. It is concluded that integrin-modulating substances offer significant promise as female-controlled means for preventing sexual transmission of HIV (whatever entity acts as HIV vector in semen and other penile secretions) and as female-controlled contraceptives.

Original language	English (US)
Pages (from-to)	271-290
Number of pages	20
Journal	Journal of Reproductive Immunology
Volume	41
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-0378(98)00064-3
State	Published - Nov 1 1998

Keywords

CD4- independent HIV transmission
Integrin-mediated adhesion
Integrin-mediated fusion
LFA-1
Oocyte penetration
VLA-4

ASJC Scopus subject areas

Immunology
Reproductive Medicine

Access to Document

10.1016/S0165-0378(98)00064-3

Fingerprint Dive into the research topics of 'Modulation of integrin function inhibits HIV transmission to epithelial cells and fertilization'. Together they form a unique fingerprint.

Cite this

@article{af64cf83694645498720f1808f75db0b,

title = "Modulation of integrin function inhibits HIV transmission to epithelial cells and fertilization",

abstract = "Integrin-mediated adhesive interactions are viewed in the context of HIV transmission to susceptible cells and fertilization. The ability of a low- molecular-weight non-peptide integrin modulator to inhibit HIV infection (virus-to-cell and cell-to-cell) and sperm-egg fusion is demonstrated. It is concluded that integrin-modulating substances offer significant promise as female-controlled means for preventing sexual transmission of HIV (whatever entity acts as HIV vector in semen and other penile secretions) and as female-controlled contraceptives.",

keywords = "CD4- independent HIV transmission, Integrin-mediated adhesion, Integrin-mediated fusion, LFA-1, Oocyte penetration, VLA-4",

author = "Davidson, {John B.} and Douglas, {Gordon C}",

year = "1998",

month = nov,

day = "1",

doi = "10.1016/S0165-0378(98)00064-3",

language = "English (US)",

volume = "41",

pages = "271--290",

journal = "Journal of Reproductive Immunology",

issn = "0165-0378",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - Modulation of integrin function inhibits HIV transmission to epithelial cells and fertilization

AU - Davidson, John B.

AU - Douglas, Gordon C

PY - 1998/11/1

Y1 - 1998/11/1

N2 - Integrin-mediated adhesive interactions are viewed in the context of HIV transmission to susceptible cells and fertilization. The ability of a low- molecular-weight non-peptide integrin modulator to inhibit HIV infection (virus-to-cell and cell-to-cell) and sperm-egg fusion is demonstrated. It is concluded that integrin-modulating substances offer significant promise as female-controlled means for preventing sexual transmission of HIV (whatever entity acts as HIV vector in semen and other penile secretions) and as female-controlled contraceptives.

AB - Integrin-mediated adhesive interactions are viewed in the context of HIV transmission to susceptible cells and fertilization. The ability of a low- molecular-weight non-peptide integrin modulator to inhibit HIV infection (virus-to-cell and cell-to-cell) and sperm-egg fusion is demonstrated. It is concluded that integrin-modulating substances offer significant promise as female-controlled means for preventing sexual transmission of HIV (whatever entity acts as HIV vector in semen and other penile secretions) and as female-controlled contraceptives.

KW - CD4- independent HIV transmission

KW - Integrin-mediated adhesion

KW - Integrin-mediated fusion

KW - LFA-1

KW - Oocyte penetration

KW - VLA-4

UR - http://www.scopus.com/inward/record.url?scp=0032415084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032415084&partnerID=8YFLogxK

U2 - 10.1016/S0165-0378(98)00064-3

DO - 10.1016/S0165-0378(98)00064-3

M3 - Article

C2 - 10213316

AN - SCOPUS:0032415084

VL - 41

SP - 271

EP - 290

JO - Journal of Reproductive Immunology

JF - Journal of Reproductive Immunology

SN - 0165-0378

IS - 1-2

ER -

Modulation of integrin function inhibits HIV transmission to epithelial cells and fertilization

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this