Modulation of endothelial progenitor cell number and function with n-3 polyunsaturated fatty acids

Sridevi Devaraj, Alexander Chien, Bhavana Rao, Xinpu Chen, Ishwarlal Jialal

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Endothelial dysfunction is pivotal in atherosclerosis. Endothelial progenitor cells (EPC) predict cardiovascular events and could serve as a cellular biomarker of endothelial function. Epidemiological studies suggest the benefits of omega 3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on cardiovascular health. However, there is a paucity of data on the effect of n-3 PUFA on EPC number and functionality. Incubation with DHA and EPA, either alone or in combination significantly increased the number of EPCs and colony forming units (CFU). In addition, co-incubation with DHA + EPA, significantly enhanced EPC migratory capacity, adhesive properties and greater incorporation into tubules. Thus, EPA + DHA are effective in improving EPC number and functionality in-vitro. Future studies will test the effect of n-3 PUFA supplementation on EPC number and function in-vivo and will elucidate plausible mechanisms.

Original languageEnglish (US)
Pages (from-to)94-97
Number of pages4
JournalAtherosclerosis
Volume228
Issue number1
DOIs
StatePublished - May 2013

Fingerprint

Omega-3 Fatty Acids
Eicosapentaenoic Acid
Docosahexaenoic Acids
Cell Count
Unsaturated Fatty Acids
Adhesives
Epidemiologic Studies
Atherosclerosis
Stem Cells
Biomarkers
Endothelial Progenitor Cells
Health

Keywords

  • Diet
  • EPC
  • Fatty acids
  • Fish oils
  • Inflammation
  • N-3 PUFA

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Modulation of endothelial progenitor cell number and function with n-3 polyunsaturated fatty acids. / Devaraj, Sridevi; Chien, Alexander; Rao, Bhavana; Chen, Xinpu; Jialal, Ishwarlal.

In: Atherosclerosis, Vol. 228, No. 1, 05.2013, p. 94-97.

Research output: Contribution to journalArticle

Devaraj, Sridevi ; Chien, Alexander ; Rao, Bhavana ; Chen, Xinpu ; Jialal, Ishwarlal. / Modulation of endothelial progenitor cell number and function with n-3 polyunsaturated fatty acids. In: Atherosclerosis. 2013 ; Vol. 228, No. 1. pp. 94-97.
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