Modulation of cutaneous wound healing by ozone: Differences between young and aged mice

Yunsook Lim; Anh D. Phung; Ana M. Corbacho; Hnin Hnin Aung; Emanuela Maioli; Abraham Z. Reznick; Carroll E Cross; Paul A. Davis; Giuseppe Valacchi

doi:10.1016/j.toxlet.2005.06.013

Modulation of cutaneous wound healing by ozone: Differences between young and aged mice

Yunsook Lim, Anh D. Phung, Ana M. Corbacho, Hnin Hnin Aung, Emanuela Maioli, Abraham Z. Reznick, Carroll E Cross, Paul A. Davis, Giuseppe Valacchi

Pulmonary, Critical Care, and Sleep Medicine

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Cutaneous tissues are frequently exposed to prooxidative environments, including UV radiation and air pollutants. Among the latter, ozone (O ₃) is of particular concern because of its high and dominating presence in photochemical smog. It is well known that O₃ depletes small molecular weight antioxidants, oxidizes proteins, induces lipid peroxidation and activates cellular responses in various tissues. Using an in vivo model (SKH-1 hairless mice), the interaction between O₃ exposure (0. 5 ppm x 6 h/day) and age was examined in relation to cutaneous wound healing. Compared to younger (8 weeks) mice, older (18 months) mice exposed to O₃ (day 0 to day 9 after wounding) exhibited delayed wound closure, increased lipid peroxidation (measured as 4-HNE protein adducts) and protein oxidation (measured as carbonyls concentration) and decreased levels of P-IκBα and TGFβ protein. These findings support the hypothesis that oxidant pollutant exposure and age interact so as to disrupt normal wound healing processes.

Original language	English (US)
Pages (from-to)	127-134
Number of pages	8
Journal	Toxicology Letters
Volume	160
Issue number	2
DOIs	https://doi.org/10.1016/j.toxlet.2005.06.013
State	Published - Jan 5 2006

Keywords

Aging
Lipid peroxidation
NFκB
Ozone
TGFβ
Wound healing

ASJC Scopus subject areas

Toxicology

Access to Document

10.1016/j.toxlet.2005.06.013

Fingerprint Dive into the research topics of 'Modulation of cutaneous wound healing by ozone: Differences between young and aged mice'. Together they form a unique fingerprint.

Cite this

Modulation of cutaneous wound healing by ozone : Differences between young and aged mice. / Lim, Yunsook; Phung, Anh D.; Corbacho, Ana M.; Aung, Hnin Hnin; Maioli, Emanuela; Reznick, Abraham Z.; Cross, Carroll E; Davis, Paul A.; Valacchi, Giuseppe.

In: Toxicology Letters, Vol. 160, No. 2, 05.01.2006, p. 127-134.

Research output: Contribution to journal › Article › peer-review

@article{fe450a8de7e5406eae7562cdda56af35,

title = "Modulation of cutaneous wound healing by ozone: Differences between young and aged mice",

abstract = "Cutaneous tissues are frequently exposed to prooxidative environments, including UV radiation and air pollutants. Among the latter, ozone (O 3) is of particular concern because of its high and dominating presence in photochemical smog. It is well known that O3 depletes small molecular weight antioxidants, oxidizes proteins, induces lipid peroxidation and activates cellular responses in various tissues. Using an in vivo model (SKH-1 hairless mice), the interaction between O3 exposure (0. 5 ppm x 6 h/day) and age was examined in relation to cutaneous wound healing. Compared to younger (8 weeks) mice, older (18 months) mice exposed to O3 (day 0 to day 9 after wounding) exhibited delayed wound closure, increased lipid peroxidation (measured as 4-HNE protein adducts) and protein oxidation (measured as carbonyls concentration) and decreased levels of P-IκBα and TGFβ protein. These findings support the hypothesis that oxidant pollutant exposure and age interact so as to disrupt normal wound healing processes.",

keywords = "Aging, Lipid peroxidation, NFκB, Ozone, TGFβ, Wound healing",

author = "Yunsook Lim and Phung, {Anh D.} and Corbacho, {Ana M.} and Aung, {Hnin Hnin} and Emanuela Maioli and Reznick, {Abraham Z.} and Cross, {Carroll E} and Davis, {Paul A.} and Giuseppe Valacchi",

year = "2006",

month = jan,

day = "5",

doi = "10.1016/j.toxlet.2005.06.013",

language = "English (US)",

volume = "160",

pages = "127--134",

journal = "Toxicology Letters",

issn = "0378-4274",

publisher = "Elsevier BV",

number = "2",

}

TY - JOUR

T1 - Modulation of cutaneous wound healing by ozone

T2 - Differences between young and aged mice

AU - Lim, Yunsook

AU - Phung, Anh D.

AU - Corbacho, Ana M.

AU - Aung, Hnin Hnin

AU - Maioli, Emanuela

AU - Reznick, Abraham Z.

AU - Cross, Carroll E

AU - Davis, Paul A.

AU - Valacchi, Giuseppe

PY - 2006/1/5

Y1 - 2006/1/5

N2 - Cutaneous tissues are frequently exposed to prooxidative environments, including UV radiation and air pollutants. Among the latter, ozone (O 3) is of particular concern because of its high and dominating presence in photochemical smog. It is well known that O3 depletes small molecular weight antioxidants, oxidizes proteins, induces lipid peroxidation and activates cellular responses in various tissues. Using an in vivo model (SKH-1 hairless mice), the interaction between O3 exposure (0. 5 ppm x 6 h/day) and age was examined in relation to cutaneous wound healing. Compared to younger (8 weeks) mice, older (18 months) mice exposed to O3 (day 0 to day 9 after wounding) exhibited delayed wound closure, increased lipid peroxidation (measured as 4-HNE protein adducts) and protein oxidation (measured as carbonyls concentration) and decreased levels of P-IκBα and TGFβ protein. These findings support the hypothesis that oxidant pollutant exposure and age interact so as to disrupt normal wound healing processes.

AB - Cutaneous tissues are frequently exposed to prooxidative environments, including UV radiation and air pollutants. Among the latter, ozone (O 3) is of particular concern because of its high and dominating presence in photochemical smog. It is well known that O3 depletes small molecular weight antioxidants, oxidizes proteins, induces lipid peroxidation and activates cellular responses in various tissues. Using an in vivo model (SKH-1 hairless mice), the interaction between O3 exposure (0. 5 ppm x 6 h/day) and age was examined in relation to cutaneous wound healing. Compared to younger (8 weeks) mice, older (18 months) mice exposed to O3 (day 0 to day 9 after wounding) exhibited delayed wound closure, increased lipid peroxidation (measured as 4-HNE protein adducts) and protein oxidation (measured as carbonyls concentration) and decreased levels of P-IκBα and TGFβ protein. These findings support the hypothesis that oxidant pollutant exposure and age interact so as to disrupt normal wound healing processes.

KW - Aging

KW - Lipid peroxidation

KW - NFκB

KW - Ozone

KW - TGFβ

KW - Wound healing

UR - http://www.scopus.com/inward/record.url?scp=27644577597&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27644577597&partnerID=8YFLogxK

U2 - 10.1016/j.toxlet.2005.06.013

DO - 10.1016/j.toxlet.2005.06.013

M3 - Article

C2 - 16129572

AN - SCOPUS:27644577597

VL - 160

SP - 127

EP - 134

JO - Toxicology Letters

JF - Toxicology Letters

SN - 0378-4274

IS - 2

ER -

Modulation of cutaneous wound healing by ozone: Differences between young and aged mice

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this