Modulation of contractility in failing human myocytes by reverse-mode Na/Ca exchange

Valentino Piacentino, Christopher R. Weber, John P. Gaughan, Kenneth B. Margulies, Donald M Bers, Steven R. Houser

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A decrease in the peak systolic [Ca]i and slow decay of the Cai transient are common features of the end-stage failing human ventricular myocyte and may underlie the contractile abnormalities observed in congestive heart failure. The role of the Na/Ca exchanger has been a great area of interest given the changes observed at the molecular level. Results from these experiments have been inconsistent, however, and therefore cellular-based experiments may be required to characterize the role of the Na/Ca exchanger in failing human myocardium. We review recent data that suggest an increased ability of the Na/Ca exchanger to transport Ca into the cytoplasm in failing human myocytes. We hypothesize that this increased Ca influx can explain the slowed decay and impaired relaxation of failing human ventricular myocytes.

Original languageEnglish (US)
Pages (from-to)466-471
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume976
StatePublished - 2002
Externally publishedYes

Fingerprint

Muscle Cells
Modulation
Experiments
Myocardium
Cytoplasm
Heart Failure
Decay
Experiment

Keywords

  • Cardiac Na/Ca exchange
  • Contractility
  • Heart failure
  • Sarcoplasmic reticulum

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Piacentino, V., Weber, C. R., Gaughan, J. P., Margulies, K. B., Bers, D. M., & Houser, S. R. (2002). Modulation of contractility in failing human myocytes by reverse-mode Na/Ca exchange. Annals of the New York Academy of Sciences, 976, 466-471.

Modulation of contractility in failing human myocytes by reverse-mode Na/Ca exchange. / Piacentino, Valentino; Weber, Christopher R.; Gaughan, John P.; Margulies, Kenneth B.; Bers, Donald M; Houser, Steven R.

In: Annals of the New York Academy of Sciences, Vol. 976, 2002, p. 466-471.

Research output: Contribution to journalArticle

Piacentino, V, Weber, CR, Gaughan, JP, Margulies, KB, Bers, DM & Houser, SR 2002, 'Modulation of contractility in failing human myocytes by reverse-mode Na/Ca exchange', Annals of the New York Academy of Sciences, vol. 976, pp. 466-471.
Piacentino, Valentino ; Weber, Christopher R. ; Gaughan, John P. ; Margulies, Kenneth B. ; Bers, Donald M ; Houser, Steven R. / Modulation of contractility in failing human myocytes by reverse-mode Na/Ca exchange. In: Annals of the New York Academy of Sciences. 2002 ; Vol. 976. pp. 466-471.
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