Modulation of cell adhesion and motility in the immune system by Myo1f

Sangwon V. Kim, Wajahat Z. Mehal, Xuemei Dong, Volkmar Heinrich, Marc Pypaert, Ira Mellman, Micah Dembo, Mark S. Mooseker, Dianqing Wu, Richard A. Flavell

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Although class I myosins are known to play a wide range of roles, the physiological function of long-tailed class I myosins in vertebrates remains elusive. We demonstrated that one of these proteins, Myo1f, is expressed predominantly in the mammalian immune system. Cells from Myo1f-deficient mice exhibited abnormally increased adhesion and reduced motility, resulting from augmented exocytosis of β2 integrin-containing granules. Also, the cortical actin that co-localizes with Myo1f was reduced in Myo1f-deficient cells. In vivo, Myo1f-deficient mice showed increased susceptibility to infection by Listeria monocytogenes and an impaired neutrophil response. Thus, Myo1f directs immune cell motility and innate host defense against infection.

Original languageEnglish (US)
Pages (from-to)136-139
Number of pages4
JournalScience
Volume314
Issue number5796
DOIs
StatePublished - Oct 6 2006

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Myosin Type I
Cell Adhesion
Cell Movement
Immune System
Exocytosis
Listeria monocytogenes
Infection
Integrins
Vertebrates
Actins
Neutrophils
Proteins

ASJC Scopus subject areas

  • General

Cite this

Kim, S. V., Mehal, W. Z., Dong, X., Heinrich, V., Pypaert, M., Mellman, I., ... Flavell, R. A. (2006). Modulation of cell adhesion and motility in the immune system by Myo1f. Science, 314(5796), 136-139. https://doi.org/10.1126/science.1131920

Modulation of cell adhesion and motility in the immune system by Myo1f. / Kim, Sangwon V.; Mehal, Wajahat Z.; Dong, Xuemei; Heinrich, Volkmar; Pypaert, Marc; Mellman, Ira; Dembo, Micah; Mooseker, Mark S.; Wu, Dianqing; Flavell, Richard A.

In: Science, Vol. 314, No. 5796, 06.10.2006, p. 136-139.

Research output: Contribution to journalArticle

Kim, SV, Mehal, WZ, Dong, X, Heinrich, V, Pypaert, M, Mellman, I, Dembo, M, Mooseker, MS, Wu, D & Flavell, RA 2006, 'Modulation of cell adhesion and motility in the immune system by Myo1f', Science, vol. 314, no. 5796, pp. 136-139. https://doi.org/10.1126/science.1131920
Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I et al. Modulation of cell adhesion and motility in the immune system by Myo1f. Science. 2006 Oct 6;314(5796):136-139. https://doi.org/10.1126/science.1131920
Kim, Sangwon V. ; Mehal, Wajahat Z. ; Dong, Xuemei ; Heinrich, Volkmar ; Pypaert, Marc ; Mellman, Ira ; Dembo, Micah ; Mooseker, Mark S. ; Wu, Dianqing ; Flavell, Richard A. / Modulation of cell adhesion and motility in the immune system by Myo1f. In: Science. 2006 ; Vol. 314, No. 5796. pp. 136-139.
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