Modulation of CD6 function through interaction with Galectin-1 and -3

Cristina Escoda-Ferran, Esther Carrasco, Miguel Caballero-Baños, Cristina Miró-Julià, Mario Martínez-Florensa, Marta Consuegra-Fernández, Vanesa G. Martínez, Fu-Tong Liu, Francisco Lozano

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

CD6 is a lymphocyte glycoprotein receptor that physically associates with the antigen-specific receptor complex at the center of the immunological synapse, where it interacts with its ligand CD166/ALCAM. The present work reports the carbohydrate-dependent interaction of CD6 and CD166/ALCAM with Galectin-1 and -3, two well-known soluble mammalian lectins. Both galectins interfered with superantigen-induced T cell proliferation and cell adhesion phenomena mediated by the CD6-CD166/ALCAM pair, while CD6 expression protected cells from galectin-induced apoptosis. The results suggest that interaction of Galectin-1 and -3 with CD6 and CD166/ALCAM might modulate some relevant aspects of T cell physiology.

Original languageEnglish (US)
Pages (from-to)2805-2813
Number of pages9
JournalFEBS Letters
Volume588
Issue number17
DOIs
StatePublished - Aug 25 2014

Keywords

  • ALCAM/CD166
  • Apoptosis
  • CD6
  • Cell adhesion
  • Galectin
  • T-cell activation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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