Modulation of CD6 function through interaction with Galectin-1 and -3

Cristina Escoda-Ferran, Esther Carrasco, Miguel Caballero-Baños, Cristina Miró-Julià, Mario Martínez-Florensa, Marta Consuegra-Fernández, Vanesa G. Martínez, Fu-Tong Liu, Francisco Lozano

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

CD6 is a lymphocyte glycoprotein receptor that physically associates with the antigen-specific receptor complex at the center of the immunological synapse, where it interacts with its ligand CD166/ALCAM. The present work reports the carbohydrate-dependent interaction of CD6 and CD166/ALCAM with Galectin-1 and -3, two well-known soluble mammalian lectins. Both galectins interfered with superantigen-induced T cell proliferation and cell adhesion phenomena mediated by the CD6-CD166/ALCAM pair, while CD6 expression protected cells from galectin-induced apoptosis. The results suggest that interaction of Galectin-1 and -3 with CD6 and CD166/ALCAM might modulate some relevant aspects of T cell physiology.

Original languageEnglish (US)
Pages (from-to)2805-2813
Number of pages9
JournalFEBS Letters
Volume588
Issue number17
DOIs
StatePublished - Aug 25 2014

Fingerprint

Activated-Leukocyte Cell Adhesion Molecule
Galectin 1
Galectin 3
Modulation
Galectins
T-cells
Immunological Synapses
T-Lymphocytes
Cell Physiological Phenomena
Superantigens
Antigen Receptors
Lymphocytes
Cell adhesion
Physiology
Cell proliferation
Lectins
Cell Adhesion
Glycoproteins
Carbohydrates
Cell Proliferation

Keywords

  • ALCAM/CD166
  • Apoptosis
  • CD6
  • Cell adhesion
  • Galectin
  • T-cell activation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Escoda-Ferran, C., Carrasco, E., Caballero-Baños, M., Miró-Julià, C., Martínez-Florensa, M., Consuegra-Fernández, M., ... Lozano, F. (2014). Modulation of CD6 function through interaction with Galectin-1 and -3. FEBS Letters, 588(17), 2805-2813. https://doi.org/10.1016/j.febslet.2014.05.064

Modulation of CD6 function through interaction with Galectin-1 and -3. / Escoda-Ferran, Cristina; Carrasco, Esther; Caballero-Baños, Miguel; Miró-Julià, Cristina; Martínez-Florensa, Mario; Consuegra-Fernández, Marta; Martínez, Vanesa G.; Liu, Fu-Tong; Lozano, Francisco.

In: FEBS Letters, Vol. 588, No. 17, 25.08.2014, p. 2805-2813.

Research output: Contribution to journalArticle

Escoda-Ferran, C, Carrasco, E, Caballero-Baños, M, Miró-Julià, C, Martínez-Florensa, M, Consuegra-Fernández, M, Martínez, VG, Liu, F-T & Lozano, F 2014, 'Modulation of CD6 function through interaction with Galectin-1 and -3', FEBS Letters, vol. 588, no. 17, pp. 2805-2813. https://doi.org/10.1016/j.febslet.2014.05.064
Escoda-Ferran C, Carrasco E, Caballero-Baños M, Miró-Julià C, Martínez-Florensa M, Consuegra-Fernández M et al. Modulation of CD6 function through interaction with Galectin-1 and -3. FEBS Letters. 2014 Aug 25;588(17):2805-2813. https://doi.org/10.1016/j.febslet.2014.05.064
Escoda-Ferran, Cristina ; Carrasco, Esther ; Caballero-Baños, Miguel ; Miró-Julià, Cristina ; Martínez-Florensa, Mario ; Consuegra-Fernández, Marta ; Martínez, Vanesa G. ; Liu, Fu-Tong ; Lozano, Francisco. / Modulation of CD6 function through interaction with Galectin-1 and -3. In: FEBS Letters. 2014 ; Vol. 588, No. 17. pp. 2805-2813.
@article{bab28b971a504eef84066a185a7d7af8,
title = "Modulation of CD6 function through interaction with Galectin-1 and -3",
abstract = "CD6 is a lymphocyte glycoprotein receptor that physically associates with the antigen-specific receptor complex at the center of the immunological synapse, where it interacts with its ligand CD166/ALCAM. The present work reports the carbohydrate-dependent interaction of CD6 and CD166/ALCAM with Galectin-1 and -3, two well-known soluble mammalian lectins. Both galectins interfered with superantigen-induced T cell proliferation and cell adhesion phenomena mediated by the CD6-CD166/ALCAM pair, while CD6 expression protected cells from galectin-induced apoptosis. The results suggest that interaction of Galectin-1 and -3 with CD6 and CD166/ALCAM might modulate some relevant aspects of T cell physiology.",
keywords = "ALCAM/CD166, Apoptosis, CD6, Cell adhesion, Galectin, T-cell activation",
author = "Cristina Escoda-Ferran and Esther Carrasco and Miguel Caballero-Ba{\~n}os and Cristina Mir{\'o}-Juli{\`a} and Mario Mart{\'i}nez-Florensa and Marta Consuegra-Fern{\'a}ndez and Mart{\'i}nez, {Vanesa G.} and Fu-Tong Liu and Francisco Lozano",
year = "2014",
month = "8",
day = "25",
doi = "10.1016/j.febslet.2014.05.064",
language = "English (US)",
volume = "588",
pages = "2805--2813",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "17",

}

TY - JOUR

T1 - Modulation of CD6 function through interaction with Galectin-1 and -3

AU - Escoda-Ferran, Cristina

AU - Carrasco, Esther

AU - Caballero-Baños, Miguel

AU - Miró-Julià, Cristina

AU - Martínez-Florensa, Mario

AU - Consuegra-Fernández, Marta

AU - Martínez, Vanesa G.

AU - Liu, Fu-Tong

AU - Lozano, Francisco

PY - 2014/8/25

Y1 - 2014/8/25

N2 - CD6 is a lymphocyte glycoprotein receptor that physically associates with the antigen-specific receptor complex at the center of the immunological synapse, where it interacts with its ligand CD166/ALCAM. The present work reports the carbohydrate-dependent interaction of CD6 and CD166/ALCAM with Galectin-1 and -3, two well-known soluble mammalian lectins. Both galectins interfered with superantigen-induced T cell proliferation and cell adhesion phenomena mediated by the CD6-CD166/ALCAM pair, while CD6 expression protected cells from galectin-induced apoptosis. The results suggest that interaction of Galectin-1 and -3 with CD6 and CD166/ALCAM might modulate some relevant aspects of T cell physiology.

AB - CD6 is a lymphocyte glycoprotein receptor that physically associates with the antigen-specific receptor complex at the center of the immunological synapse, where it interacts with its ligand CD166/ALCAM. The present work reports the carbohydrate-dependent interaction of CD6 and CD166/ALCAM with Galectin-1 and -3, two well-known soluble mammalian lectins. Both galectins interfered with superantigen-induced T cell proliferation and cell adhesion phenomena mediated by the CD6-CD166/ALCAM pair, while CD6 expression protected cells from galectin-induced apoptosis. The results suggest that interaction of Galectin-1 and -3 with CD6 and CD166/ALCAM might modulate some relevant aspects of T cell physiology.

KW - ALCAM/CD166

KW - Apoptosis

KW - CD6

KW - Cell adhesion

KW - Galectin

KW - T-cell activation

UR - http://www.scopus.com/inward/record.url?scp=84906218046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906218046&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2014.05.064

DO - 10.1016/j.febslet.2014.05.064

M3 - Article

C2 - 24945728

AN - SCOPUS:84906218046

VL - 588

SP - 2805

EP - 2813

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 17

ER -