Modulation of bradykinin-induced gastric-cardiovascular reflexes by histamine

Charles L Stebbins, G. L. Stahl, S. J. Theodossy, J. C. Longhurst

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Both histamine and bradykinin induce gastric-cardiovascular reflexes and are released during several pathophysiological conditions. This study examined the possibility that histamine modulates the magnitude of the reflex response to stimulation by bradykinin. Thus in chloralose anesthetized cats, the cardiovascular response to stimulation of the gastric serosa with 1 μg/ml bradykinin was monitored before and after topical application of 100 μg/ml histamine (n = 6) or 1 mg/ml diphenhydramine (H1-receptor antagonist) and histamine (n = 5). After application of histamine, bradykinin-induced increases in mean arterial pressure and left ventricular pressure were attenuated by 23 and 27%, respectively. Conversely, when the H1-receptors on the serosal surface of the stomach were blocked (n = 5) before application of histamine, the pressor response to bradykinin was augmented by 26%. To determine the afferents that might contribute to the attenuating effect of histamine, we recorded single unit activity in 14 Aδ and 21 C visceral afferent fibers in response to bradykinin stimulation before and after histamine stimulation. We observed that the impulse activity of 10 of the Aδ and 14 of the C fibers to bradykinin stimulation was reduced after treatment with histamine. These results suggest that histamine induces an inhibitory effect on the nerve endings of visceral Aδ and C fibers to the action of bradykinin through an H1-receptor mechanism. This inhibitory effect attenuates the magnitude of the consequent cardiovascular reflex response.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume262
Issue number1 31-1
StatePublished - 1992

Fingerprint

Bradykinin
Histamine
Reflex
Stomach
Histamine H1 Receptors
Unmyelinated Nerve Fibers
Visceral Afferents
Histamine H1 Antagonists
Myelinated Nerve Fibers
Diphenhydramine
Serous Membrane
Chloralose
Nerve Endings
Ventricular Pressure
Arterial Pressure
Cats

Keywords

  • Aδ and C fibers
  • Cats
  • Diphenhydramine

ASJC Scopus subject areas

  • Physiology

Cite this

Modulation of bradykinin-induced gastric-cardiovascular reflexes by histamine. / Stebbins, Charles L; Stahl, G. L.; Theodossy, S. J.; Longhurst, J. C.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 262, No. 1 31-1, 1992.

Research output: Contribution to journalArticle

Stebbins, Charles L ; Stahl, G. L. ; Theodossy, S. J. ; Longhurst, J. C. / Modulation of bradykinin-induced gastric-cardiovascular reflexes by histamine. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1992 ; Vol. 262, No. 1 31-1.
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