Abstract
Young rhesus monkeys (Macaca mulatto, n = 14) 25-30 mo of age were fed a zinc-deficient (ZD) diet (2 μg Zn/g diet) (moderate zinc deprivation) over 15 week. The ZD diet period was compared with a zinc-adequate (ZA) diet period (50 μg Zn/g diet) of the same duration, which either preceded or followed it (crossover design). Plasma zinc was lower at the end of the ZD than after the ZA period. There were no overt signs of zinc deficiency or effects on growth rate. Spontaneous motor activity was lower and performance of a visual-attention task and short-term-memory task were poorer during the ZD period than during the ZA period. Behavioral effects were detected as changes from individual baseline values, and often represented a failure to improve. The results suggests that dietary zinc deprivation can modulate behavior in prepubertal monkeys without affecting growth.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 238-243 |
| Number of pages | 6 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 60 |
| Issue number | 2 |
| State | Published - Aug 1994 |
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Keywords
- Behavior
- Childhood
- Cognition
- Growth
- Monkeys
- Prepuberty
- Supplements
- Taste
- Zinc deprivation
ASJC Scopus subject areas
- Food Science
- Medicine (miscellaneous)
Cite this
Modulation of behavioral performance of prepubertal monkeys by moderate dietary zinc deprivation. / Golub, Mari S.; Takeuchi, Peter T.; Keen, Carl L; Gershwin, M. Eric; Hendrickx, Andrew G; Lonnerdal, Bo.
In: American Journal of Clinical Nutrition, Vol. 60, No. 2, 08.1994, p. 238-243.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modulation of behavioral performance of prepubertal monkeys by moderate dietary zinc deprivation
AU - Golub, Mari S.
AU - Takeuchi, Peter T.
AU - Keen, Carl L
AU - Gershwin, M. Eric
AU - Hendrickx, Andrew G
AU - Lonnerdal, Bo
PY - 1994/8
Y1 - 1994/8
N2 - Young rhesus monkeys (Macaca mulatto, n = 14) 25-30 mo of age were fed a zinc-deficient (ZD) diet (2 μg Zn/g diet) (moderate zinc deprivation) over 15 week. The ZD diet period was compared with a zinc-adequate (ZA) diet period (50 μg Zn/g diet) of the same duration, which either preceded or followed it (crossover design). Plasma zinc was lower at the end of the ZD than after the ZA period. There were no overt signs of zinc deficiency or effects on growth rate. Spontaneous motor activity was lower and performance of a visual-attention task and short-term-memory task were poorer during the ZD period than during the ZA period. Behavioral effects were detected as changes from individual baseline values, and often represented a failure to improve. The results suggests that dietary zinc deprivation can modulate behavior in prepubertal monkeys without affecting growth.
AB - Young rhesus monkeys (Macaca mulatto, n = 14) 25-30 mo of age were fed a zinc-deficient (ZD) diet (2 μg Zn/g diet) (moderate zinc deprivation) over 15 week. The ZD diet period was compared with a zinc-adequate (ZA) diet period (50 μg Zn/g diet) of the same duration, which either preceded or followed it (crossover design). Plasma zinc was lower at the end of the ZD than after the ZA period. There were no overt signs of zinc deficiency or effects on growth rate. Spontaneous motor activity was lower and performance of a visual-attention task and short-term-memory task were poorer during the ZD period than during the ZA period. Behavioral effects were detected as changes from individual baseline values, and often represented a failure to improve. The results suggests that dietary zinc deprivation can modulate behavior in prepubertal monkeys without affecting growth.
KW - Behavior
KW - Childhood
KW - Cognition
KW - Growth
KW - Monkeys
KW - Prepuberty
KW - Supplements
KW - Taste
KW - Zinc deprivation
UR - http://www.scopus.com/inward/record.url?scp=0028141915&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028141915&partnerID=8YFLogxK
M3 - Article
C2 - 8030602
AN - SCOPUS:0028141915
VL - 60
SP - 238
EP - 243
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 2
ER -