Modulation of behavioral performance of prepubertal monkeys by moderate dietary zinc deprivation

Mari S. Golub, Peter T. Takeuchi, Carl L Keen, M. Eric Gershwin, Andrew G Hendrickx, Bo Lonnerdal

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Young rhesus monkeys (Macaca mulatto, n = 14) 25-30 mo of age were fed a zinc-deficient (ZD) diet (2 μg Zn/g diet) (moderate zinc deprivation) over 15 week. The ZD diet period was compared with a zinc-adequate (ZA) diet period (50 μg Zn/g diet) of the same duration, which either preceded or followed it (crossover design). Plasma zinc was lower at the end of the ZD than after the ZA period. There were no overt signs of zinc deficiency or effects on growth rate. Spontaneous motor activity was lower and performance of a visual-attention task and short-term-memory task were poorer during the ZD period than during the ZA period. Behavioral effects were detected as changes from individual baseline values, and often represented a failure to improve. The results suggests that dietary zinc deprivation can modulate behavior in prepubertal monkeys without affecting growth.

Original languageEnglish (US)
Pages (from-to)238-243
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume60
Issue number2
StatePublished - Aug 1994

Fingerprint

Haplorhini
monkeys
Zinc
zinc
Diet
diet
Macaca
Growth
Macaca mulatta
Short-Term Memory
Cross-Over Studies
normal values
Motor Activity
duration

Keywords

  • Behavior
  • Childhood
  • Cognition
  • Growth
  • Monkeys
  • Prepuberty
  • Supplements
  • Taste
  • Zinc deprivation

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Golub, M. S., Takeuchi, P. T., Keen, C. L., Gershwin, M. E., Hendrickx, A. G., & Lonnerdal, B. (1994). Modulation of behavioral performance of prepubertal monkeys by moderate dietary zinc deprivation. American Journal of Clinical Nutrition, 60(2), 238-243.

Modulation of behavioral performance of prepubertal monkeys by moderate dietary zinc deprivation. / Golub, Mari S.; Takeuchi, Peter T.; Keen, Carl L; Gershwin, M. Eric; Hendrickx, Andrew G; Lonnerdal, Bo.

In: American Journal of Clinical Nutrition, Vol. 60, No. 2, 08.1994, p. 238-243.

Research output: Contribution to journalArticle

Golub, MS, Takeuchi, PT, Keen, CL, Gershwin, ME, Hendrickx, AG & Lonnerdal, B 1994, 'Modulation of behavioral performance of prepubertal monkeys by moderate dietary zinc deprivation', American Journal of Clinical Nutrition, vol. 60, no. 2, pp. 238-243.
Golub, Mari S. ; Takeuchi, Peter T. ; Keen, Carl L ; Gershwin, M. Eric ; Hendrickx, Andrew G ; Lonnerdal, Bo. / Modulation of behavioral performance of prepubertal monkeys by moderate dietary zinc deprivation. In: American Journal of Clinical Nutrition. 1994 ; Vol. 60, No. 2. pp. 238-243.
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