Abstract
Microfabrication technology is implemented to realize a fluidic microinstrument for the study of endothelial cell elongation and cell responsiveness to fluid flow. The microinstrument contains arrays of microchannels, 30-300 μm wide, that are fabricated by deep reactive ion etching (DRIE) of silicon and anodic bonding to glass. Silicon fluidic input/output modules, also micromachined in silicon, provide modular connections between the microchannels and off-chip devices for flow monitoring and control. Image analysis of cells cultured in microchannels shows that the cells become progressively more elongated as channel width decreases. When subjected to a fluid shear stress of 2 N/m 2, cuboidal cells grown in 200 μm wide microchannels progressively align and elongate in the direction of flow.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
| Publisher | Society of Photo-Optical Instrumentation Engineers |
| Pages | 88-94 |
| Number of pages | 7 |
| Volume | 3912 |
| State | Published - 2000 |
| Event | Micro- and Nanotechnology for Biomedical and Environmental Applications - San Jose, CA, USA Duration: Jan 26 2000 → Jan 27 2000 |
Other
| Other | Micro- and Nanotechnology for Biomedical and Environmental Applications |
|---|---|
| City | San Jose, CA, USA |
| Period | 1/26/00 → 1/27/00 |
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Condensed Matter Physics