Modular microinstrumentation for endothelial cell research

Bonnie L. Gray, Abdul I. Barakat, Deborah Lieu, Scott D. Collins, Rosemary L. Smith

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Microfabrication technology is implemented to realize a fluidic microinstrument for the study of endothelial cell elongation and cell responsiveness to fluid flow. The microinstrument contains arrays of microchannels, 30-300 μm wide, that are fabricated by deep reactive ion etching (DRIE) of silicon and anodic bonding to glass. Silicon fluidic input/output modules, also micromachined in silicon, provide modular connections between the microchannels and off-chip devices for flow monitoring and control. Image analysis of cells cultured in microchannels shows that the cells become progressively more elongated as channel width decreases. When subjected to a fluid shear stress of 2 N/m 2, cuboidal cells grown in 200 μm wide microchannels progressively align and elongate in the direction of flow.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Number of pages7
StatePublished - 2000
EventMicro- and Nanotechnology for Biomedical and Environmental Applications - San Jose, CA, USA
Duration: Jan 26 2000Jan 27 2000


OtherMicro- and Nanotechnology for Biomedical and Environmental Applications
CitySan Jose, CA, USA

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics


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