Modular indirect calorimeter suitable for long-term measurements in multipatient intensive care units

D. M. Steinhorn, A. L. Rozenberg, M. J. Boyle, J. H. Abrams, R. C. McComb, I. Gilmour, F. B. Cerra

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective: The construction of an indirect calorimeter capable of long-term automated sequential monitoring of multiple patients in adult and pediatric ICUs. Design: A prototype system utilizing modular engineering principles, including central respiratory mass spectrometer; validation by organic solvent combustion and nitrogen dilution methods, and Tissot spirometer. Setting: Surgical and pediatric ICUs in a tertiary care university hospital. Results: When expired minute volume was measured over a range of 4 to 28 L in six intubated patients, expired minute volume measured by the prototype system demonstrated a correlation coefficient of .998 compared with simultaneous expired minute volume measured by a Tissot spirometer. Organic solvent combustion demonstrated a maximum error of 3.8% for oxygen consumption (V̇O2) and an average error of 1.73 ± 1.25% (SEM). The maximum error for the respiratory quotient was 3.0%, with an average error of 1.75 ± 1.07%. V̇O2 (predicted) vs. V̇O2 (measured) demonstrated a correlation coefficient of .997. Validation with the nitrogen dilution method over a range of FIO2 from 0.21 to 0.60 demonstrated a maximum error of 7.9%, with an average error of -1.72 ± 1.1% (n = 51). Conclusions: Indirect calorimetry by means of a shared system for measurements in multiple patients in ICUs is feasible and cost effective utilizing modular principles and a centralized respiratory gas analyzer.

Original languageEnglish (US)
Pages (from-to)963-972
Number of pages10
JournalCritical Care Medicine
Volume19
Issue number7
StatePublished - 1991
Externally publishedYes

Keywords

  • Blood gas analysis
  • Calorimetry
  • Intensive care unit
  • Intubation, endotracheal
  • Microprocessors
  • Nutritional assessment
  • Oxygen consumption
  • Spectrometry, mass
  • Tidal volume

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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