Modular assembly of RanBP2-Type zinc finger domains to target single-stranded RNA

Mitchell R. O'Connell, Marylène Vandevenne, Cuong D. Nguyen, Jacqueline M. Matthews, Roland Gamsjaeger, David Segal, Joel P. MacKay

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Fingering RNA: To study the function of the variety of RNA species that have been discovered recently, sequence-specific RNA-binding molecules with tunable specificity are required. Here, the use of zinc fingers (ZFs) from the splicing factors ZRANB2 and RBM5 as potential modules for the assembly of sequence-specific RNA-binding molecules is demonstrated.

Original languageEnglish (US)
Pages (from-to)5371-5375
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number22
DOIs
StatePublished - May 29 2012

Keywords

  • protein design
  • RNA
  • zinc-fingers

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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    O'Connell, M. R., Vandevenne, M., Nguyen, C. D., Matthews, J. M., Gamsjaeger, R., Segal, D., & MacKay, J. P. (2012). Modular assembly of RanBP2-Type zinc finger domains to target single-stranded RNA. Angewandte Chemie - International Edition, 51(22), 5371-5375. https://doi.org/10.1002/anie.201200866