Modification of the association between ambient air pollution and lung function by frailty status among older adults in the cardiovascular health study

Sandrah P. Eckel, Thomas A. Louis, Paulo H M Chaves, Linda P. Fried, Helene G Margolis

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The susceptibility of older adults to the health effects of air pollution is well-recognized. Advanced age may act as a partial surrogate for conditions associated with aging. The authors investigated whether gerontologic frailty (a clinical health status metric) modified the association between ambient level of ozone or particulate matter with an aerodynamic diameter less than 10 m and lung function in 3,382 older adults using 7 years of follow-up data (1990-1997) from the Cardiovascular Health Study and its Environmental Factors Ancillary Study. Monthly average pollution and annual frailty assessments were related to up to 3 repeated measurements of lung function using cumulative summaries of pollution and frailty histories that accounted for duration as well as concentration. Frailty history was found to modify long-term associations of pollutants with forced vital capacity. For example, the decrease in forced vital capacity associated with a 70-ppb/month greater cumulative sum of monthly average ozone exposure was 12.3 mL (95 confidence interval: 10.4, 14.2) for a woman who had spent the prior 7 years prefrail or frail as compared with 4.7 mL (95 confidence interval: 3.8, 5.6) for a similar woman who was robust during all 7 years (interaction P < 0.001).

Original languageEnglish (US)
Pages (from-to)214-223
Number of pages10
JournalAmerican Journal of Epidemiology
Volume176
Issue number3
DOIs
StatePublished - Aug 2012

Fingerprint

Ozone
Vital Capacity
Air Pollution
Confidence Intervals
Lung
Particulate Matter
Health
Health Status
History

Keywords

  • aging
  • effect modifier, epidemiologic
  • environmental exposure
  • frail elderly
  • respiratory function tests

ASJC Scopus subject areas

  • Epidemiology

Cite this

Modification of the association between ambient air pollution and lung function by frailty status among older adults in the cardiovascular health study. / Eckel, Sandrah P.; Louis, Thomas A.; Chaves, Paulo H M; Fried, Linda P.; Margolis, Helene G.

In: American Journal of Epidemiology, Vol. 176, No. 3, 08.2012, p. 214-223.

Research output: Contribution to journalArticle

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