Modification of early dimethylhydrazine carcinogenesis by colonic mucosal hyperplasia

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38 Citations (Scopus)

Abstract

The interaction of colonic mucosal hyperplasia with early 1,2-dimethylhydrazine (DMH) carcinogenesis was studied in random-bred NIH Swiss mice utilizing hyperplasia-inducing Citrobacter freundii. Mice inoculated with this bacterium developed significantly more DMH focal atypia than did mice without hyperplasia following a single dose of DMH (20 mg/kg). Mice with hyperplasia also developed DMH focal atypia with diminished doses of DMH (10 and 5 mg/kg), while normal mice did not. The effect of C. freundii on early DMH carcinogenesis was shown to be due to the hyperplasia rather than to a direct interaction of the bacterium with DMH. Focal atypia arose in high incidence 1 month after a single dose of DMH (20 mg/kg) but did not appear to progress to later stages of neoplasia, since significantly fewer cases of atypia were present at 2 to 4 months among a randomized population. Colonic focal atypia may represent a reversible preneoplastic or precursor lesion as seen in other tissues, with features more aligned to neoplasia than to hyperplasia.

Original languageEnglish (US)
Pages (from-to)4451-4455
Number of pages5
JournalCancer Research
Volume40
Issue number12
StatePublished - 1980
Externally publishedYes

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Dimethylhydrazines
1,2-Dimethylhydrazine
Hyperplasia
Carcinogenesis
Citrobacter freundii
Bacteria
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Modification of early dimethylhydrazine carcinogenesis by colonic mucosal hyperplasia. / Barthold, Stephen W; Beck, D.

In: Cancer Research, Vol. 40, No. 12, 1980, p. 4451-4455.

Research output: Contribution to journalArticle

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