Modification of amygdala-kindled postictal inhibition by pentylenetetrazol and diazepam

Research output: Contribution to journalArticle

Abstract

When fully amygdala-kindled rats are electrically stimulated in grouped trials with intertrial stimulation intervals of less than 60 min, significant residual inhibition can be demonstrated. When these grouped trials of stimulation are repeated daily, additional cumulative inhibition is seen. The present study examined the effect of daily pretreatment with three doses of pentylenetetrazol (5, 10, and 20 mg/kg) and two doses of diazepam (0.5 and 2 mg/kg) on daily, grouped trial electrical stimulations of fully amygdala-kindled rats. Little or no reduction was seen in posticatal inhibition by pentylenetetrazol pretreatment including the highest dose tested in which prestimulation bursts of spiking were associated with short episodes of forelimb clonus. Pretreatment with the benzodiazepine receptor agonist, diazepam, resulted in a dose-dependent reduction in the first elicited seizure response each day compared with control trials. Subsequent daily seizure trials of diazepam-treated animals demonstrated a relatively constant degree of dose-dependent seizure suppression without evidence of further postictal inhibition. The neural substrate that governs grouped trial postictal inhibition of amygdala-kindled seizures appears to be resistent to modification by near-convulsant doses of pentylenetetrazol, an agent with a presumed GABA-mediated mechanism of action. Diazepam, an anticonvulsant with a presumed GABA-related or associated mechanism of action, suppressed seizures in a dose-dependent manner nearly equally across all trials.

Original languageEnglish (US)
Pages (from-to)626-634
Number of pages9
JournalExperimental Neurology
Volume97
Issue number3
DOIs
StatePublished - 1987

Fingerprint

Pentylenetetrazole
Diazepam
Amygdala
Seizures
gamma-Aminobutyric Acid
Convulsants
Forelimb
GABA-A Receptors
Anticonvulsants
Electric Stimulation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Modification of amygdala-kindled postictal inhibition by pentylenetetrazol and diazepam. / Albertson, Timothy E.

In: Experimental Neurology, Vol. 97, No. 3, 1987, p. 626-634.

Research output: Contribution to journalArticle

@article{6438d09f6e9a4c6e941ffe200e4f229c,
title = "Modification of amygdala-kindled postictal inhibition by pentylenetetrazol and diazepam",
abstract = "When fully amygdala-kindled rats are electrically stimulated in grouped trials with intertrial stimulation intervals of less than 60 min, significant residual inhibition can be demonstrated. When these grouped trials of stimulation are repeated daily, additional cumulative inhibition is seen. The present study examined the effect of daily pretreatment with three doses of pentylenetetrazol (5, 10, and 20 mg/kg) and two doses of diazepam (0.5 and 2 mg/kg) on daily, grouped trial electrical stimulations of fully amygdala-kindled rats. Little or no reduction was seen in posticatal inhibition by pentylenetetrazol pretreatment including the highest dose tested in which prestimulation bursts of spiking were associated with short episodes of forelimb clonus. Pretreatment with the benzodiazepine receptor agonist, diazepam, resulted in a dose-dependent reduction in the first elicited seizure response each day compared with control trials. Subsequent daily seizure trials of diazepam-treated animals demonstrated a relatively constant degree of dose-dependent seizure suppression without evidence of further postictal inhibition. The neural substrate that governs grouped trial postictal inhibition of amygdala-kindled seizures appears to be resistent to modification by near-convulsant doses of pentylenetetrazol, an agent with a presumed GABA-mediated mechanism of action. Diazepam, an anticonvulsant with a presumed GABA-related or associated mechanism of action, suppressed seizures in a dose-dependent manner nearly equally across all trials.",
author = "Albertson, {Timothy E}",
year = "1987",
doi = "10.1016/0014-4886(87)90119-1",
language = "English (US)",
volume = "97",
pages = "626--634",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Modification of amygdala-kindled postictal inhibition by pentylenetetrazol and diazepam

AU - Albertson, Timothy E

PY - 1987

Y1 - 1987

N2 - When fully amygdala-kindled rats are electrically stimulated in grouped trials with intertrial stimulation intervals of less than 60 min, significant residual inhibition can be demonstrated. When these grouped trials of stimulation are repeated daily, additional cumulative inhibition is seen. The present study examined the effect of daily pretreatment with three doses of pentylenetetrazol (5, 10, and 20 mg/kg) and two doses of diazepam (0.5 and 2 mg/kg) on daily, grouped trial electrical stimulations of fully amygdala-kindled rats. Little or no reduction was seen in posticatal inhibition by pentylenetetrazol pretreatment including the highest dose tested in which prestimulation bursts of spiking were associated with short episodes of forelimb clonus. Pretreatment with the benzodiazepine receptor agonist, diazepam, resulted in a dose-dependent reduction in the first elicited seizure response each day compared with control trials. Subsequent daily seizure trials of diazepam-treated animals demonstrated a relatively constant degree of dose-dependent seizure suppression without evidence of further postictal inhibition. The neural substrate that governs grouped trial postictal inhibition of amygdala-kindled seizures appears to be resistent to modification by near-convulsant doses of pentylenetetrazol, an agent with a presumed GABA-mediated mechanism of action. Diazepam, an anticonvulsant with a presumed GABA-related or associated mechanism of action, suppressed seizures in a dose-dependent manner nearly equally across all trials.

AB - When fully amygdala-kindled rats are electrically stimulated in grouped trials with intertrial stimulation intervals of less than 60 min, significant residual inhibition can be demonstrated. When these grouped trials of stimulation are repeated daily, additional cumulative inhibition is seen. The present study examined the effect of daily pretreatment with three doses of pentylenetetrazol (5, 10, and 20 mg/kg) and two doses of diazepam (0.5 and 2 mg/kg) on daily, grouped trial electrical stimulations of fully amygdala-kindled rats. Little or no reduction was seen in posticatal inhibition by pentylenetetrazol pretreatment including the highest dose tested in which prestimulation bursts of spiking were associated with short episodes of forelimb clonus. Pretreatment with the benzodiazepine receptor agonist, diazepam, resulted in a dose-dependent reduction in the first elicited seizure response each day compared with control trials. Subsequent daily seizure trials of diazepam-treated animals demonstrated a relatively constant degree of dose-dependent seizure suppression without evidence of further postictal inhibition. The neural substrate that governs grouped trial postictal inhibition of amygdala-kindled seizures appears to be resistent to modification by near-convulsant doses of pentylenetetrazol, an agent with a presumed GABA-mediated mechanism of action. Diazepam, an anticonvulsant with a presumed GABA-related or associated mechanism of action, suppressed seizures in a dose-dependent manner nearly equally across all trials.

UR - http://www.scopus.com/inward/record.url?scp=0023231239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023231239&partnerID=8YFLogxK

U2 - 10.1016/0014-4886(87)90119-1

DO - 10.1016/0014-4886(87)90119-1

M3 - Article

VL - 97

SP - 626

EP - 634

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 3

ER -