Modes of salmonid MHC class I and II evolution differ from the primate paradigm

B. P. Shum, L. Guethlein, L. R. Flodin, M. A. Adkison, Ronald Hedrick, R. B. Nehring, R. J.M. Stet, C. Secombes, P. Parham

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta) represent two salmonid genera separated for 15-20 million years. cDNA sequences were determined for the classical MHC class I heavy chain gene UBA and the MHC class II β-chain gene DAB from 15 rainbow and 10 brown trout. Both genes are highly polymorphic in both species and diploid in expression. The MHC class I alleles comprise several highly divergent lineages that are represented in both species and predate genera separation. The class II alleles are less divergent, highly species specific, and probably arose after genera separation. The striking difference in salmonid MHC class I and class II evolution contrasts with the situation in primates, where lineages of class II alleles have been sustained over longer periods of time relative to class I lineages. The difference may arise because salmonid MHC class I and II genes are not linked, whereas in mammals they are closely linked. A prevalent mechanism for evolving new MHC class I alleles in salmonids is recombination in intron II that shuffles α1 and α2 domains into different combinations.

Original languageEnglish (US)
Pages (from-to)3297-3308
Number of pages12
JournalJournal of Immunology
Volume166
Issue number5
DOIs
StatePublished - Mar 1 2001
Externally publishedYes

Fingerprint

Primates
Alleles
MHC Class II Genes
Trout
Oncorhynchus mykiss
Salmonidae
MHC Class I Genes
Prednisolone
Diploidy
Introns
Genetic Recombination
Genes
Mammals
Complementary DNA

ASJC Scopus subject areas

  • Immunology

Cite this

Shum, B. P., Guethlein, L., Flodin, L. R., Adkison, M. A., Hedrick, R., Nehring, R. B., ... Parham, P. (2001). Modes of salmonid MHC class I and II evolution differ from the primate paradigm. Journal of Immunology, 166(5), 3297-3308. https://doi.org/10.4049/jimmunol.166.5.3297

Modes of salmonid MHC class I and II evolution differ from the primate paradigm. / Shum, B. P.; Guethlein, L.; Flodin, L. R.; Adkison, M. A.; Hedrick, Ronald; Nehring, R. B.; Stet, R. J.M.; Secombes, C.; Parham, P.

In: Journal of Immunology, Vol. 166, No. 5, 01.03.2001, p. 3297-3308.

Research output: Contribution to journalArticle

Shum, BP, Guethlein, L, Flodin, LR, Adkison, MA, Hedrick, R, Nehring, RB, Stet, RJM, Secombes, C & Parham, P 2001, 'Modes of salmonid MHC class I and II evolution differ from the primate paradigm', Journal of Immunology, vol. 166, no. 5, pp. 3297-3308. https://doi.org/10.4049/jimmunol.166.5.3297
Shum, B. P. ; Guethlein, L. ; Flodin, L. R. ; Adkison, M. A. ; Hedrick, Ronald ; Nehring, R. B. ; Stet, R. J.M. ; Secombes, C. ; Parham, P. / Modes of salmonid MHC class I and II evolution differ from the primate paradigm. In: Journal of Immunology. 2001 ; Vol. 166, No. 5. pp. 3297-3308.
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