Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat

J. Y. Jiang, Bruce G Lyeth, M. Z. Kapasi, L. W. Jenkins, J. T. Povlishock

Research output: Contribution to journalArticlepeer-review

164 Scopus citations


The effects of moderate hypothermia on blood-brain barrier (BBB) permeability and the acute hypertensive response after moderate traumatic brain injury (TBI) in rats were examined. TBI produced increased vascular permeability to endogenous serum albumin (IgG) in normothermic rats (37.5°C) throughout the dorsal cortical gray and white matter as well as in the underlying hippocampi as visualized by immunocytochemical techniques. Vascular permeability was greatly reduced in hypothermic rats cooled to 30°C (brain temperature) prior to injury. In hypothermic rats, albumin immunoreactivity was confined to the gray-white interface between cortex and hippocampi with no involvement of the overlying cortices and greatly reduced involvement of the underlying hippocampi. The acute hypertensive response in normothermic rats peaked at 10 s after TBI (187.3 mm Hg) and returned to baseline within 50 s. In contrast, the peak acute hypertensive response was significantly (P<0.05) reduced in hypothermic rats (154.8 mm Hg, 10 s after TBI) and returned to baseline at 30 s after injury. These results demonstrate that moderate hypothermia greatly reduces endogenous vascular protein-tracer passage into and perhaps through the brain. This reduction may, in part, be related to hypothermia-induced modulation of the systemic blood pressure response to TBI.

Original languageEnglish (US)
Pages (from-to)495-500
Number of pages6
JournalActa Neuropathologica
Issue number5
StatePublished - Oct 1992
Externally publishedYes


  • Blood-brain barrier
  • Hypertension
  • Hypothermia
  • Rat
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology


Dive into the research topics of 'Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat'. Together they form a unique fingerprint.

Cite this