Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation

Robin H Steinhorn, F. C. Morin, J. R. Fineman

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

At birth, a marked decrease in pulmonary vascular resistance allows the lung to establish gas exchange. Persistent pulmonary hypertension of the newborn (PPHN) occurs when this normal adaptation of gas exchange does not occur. We review animal models used to study the pathogenesis and treatment of PPHN. Both acute models, such as acute hypoxia and infusion of vasoconstrictors, and chronic models of PPHN created both before and immediately after birth are described. Inhaled nitric oxide is an important emerging therapy for PPHN. We review nitric oxide receptor mechanisms, including soluble guanylate cyclase, which produces cGMP when stimulated by nitric oxide, and phosphodiesterases, which control the intensity and duration of cGMP signal transduction. A better understanding of these mechanisms of regulation of vascular tone may lead to safer use of nitric oxide and improved clinical outcomes.

Original languageEnglish (US)
Pages (from-to)393-408
Number of pages16
JournalSeminars in Perinatology
Volume21
Issue number5
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Persistent Fetal Circulation Syndrome
Cyclic GMP
Vasodilation
Lung
Nitric Oxide
Gases
Parturition
Phosphoric Diester Hydrolases
Vasoconstrictor Agents
Vascular Resistance
Blood Vessels
Signal Transduction
Animal Models

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation. / Steinhorn, Robin H; Morin, F. C.; Fineman, J. R.

In: Seminars in Perinatology, Vol. 21, No. 5, 1997, p. 393-408.

Research output: Contribution to journalArticle

@article{2548fdbdfbe54de29b0249acb555fccc,
title = "Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation",
abstract = "At birth, a marked decrease in pulmonary vascular resistance allows the lung to establish gas exchange. Persistent pulmonary hypertension of the newborn (PPHN) occurs when this normal adaptation of gas exchange does not occur. We review animal models used to study the pathogenesis and treatment of PPHN. Both acute models, such as acute hypoxia and infusion of vasoconstrictors, and chronic models of PPHN created both before and immediately after birth are described. Inhaled nitric oxide is an important emerging therapy for PPHN. We review nitric oxide receptor mechanisms, including soluble guanylate cyclase, which produces cGMP when stimulated by nitric oxide, and phosphodiesterases, which control the intensity and duration of cGMP signal transduction. A better understanding of these mechanisms of regulation of vascular tone may lead to safer use of nitric oxide and improved clinical outcomes.",
author = "Steinhorn, {Robin H} and Morin, {F. C.} and Fineman, {J. R.}",
year = "1997",
doi = "10.1016/S0146-0005(97)80005-5",
language = "English (US)",
volume = "21",
pages = "393--408",
journal = "Seminars in Perinatology",
issn = "0146-0005",
publisher = "W.B. Saunders Ltd",
number = "5",

}

TY - JOUR

T1 - Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation

AU - Steinhorn, Robin H

AU - Morin, F. C.

AU - Fineman, J. R.

PY - 1997

Y1 - 1997

N2 - At birth, a marked decrease in pulmonary vascular resistance allows the lung to establish gas exchange. Persistent pulmonary hypertension of the newborn (PPHN) occurs when this normal adaptation of gas exchange does not occur. We review animal models used to study the pathogenesis and treatment of PPHN. Both acute models, such as acute hypoxia and infusion of vasoconstrictors, and chronic models of PPHN created both before and immediately after birth are described. Inhaled nitric oxide is an important emerging therapy for PPHN. We review nitric oxide receptor mechanisms, including soluble guanylate cyclase, which produces cGMP when stimulated by nitric oxide, and phosphodiesterases, which control the intensity and duration of cGMP signal transduction. A better understanding of these mechanisms of regulation of vascular tone may lead to safer use of nitric oxide and improved clinical outcomes.

AB - At birth, a marked decrease in pulmonary vascular resistance allows the lung to establish gas exchange. Persistent pulmonary hypertension of the newborn (PPHN) occurs when this normal adaptation of gas exchange does not occur. We review animal models used to study the pathogenesis and treatment of PPHN. Both acute models, such as acute hypoxia and infusion of vasoconstrictors, and chronic models of PPHN created both before and immediately after birth are described. Inhaled nitric oxide is an important emerging therapy for PPHN. We review nitric oxide receptor mechanisms, including soluble guanylate cyclase, which produces cGMP when stimulated by nitric oxide, and phosphodiesterases, which control the intensity and duration of cGMP signal transduction. A better understanding of these mechanisms of regulation of vascular tone may lead to safer use of nitric oxide and improved clinical outcomes.

UR - http://www.scopus.com/inward/record.url?scp=0030727379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030727379&partnerID=8YFLogxK

U2 - 10.1016/S0146-0005(97)80005-5

DO - 10.1016/S0146-0005(97)80005-5

M3 - Article

C2 - 9352612

AN - SCOPUS:0030727379

VL - 21

SP - 393

EP - 408

JO - Seminars in Perinatology

JF - Seminars in Perinatology

SN - 0146-0005

IS - 5

ER -