Abstract
This study investigated methodological (task, stimulus) and intersubject variability in the cortical representation of auditory processing of complex sounds, including speech. Subjects were adult seizure patients undergoing left hemisphere electrocortical mapping (ECM). We tested auditory discrimination of complex sounds, including frequency-modulated tones and speech syllables (digitized, synthesized) contrasted by phonetic features and lexical status. To measure task effects, auditory comprehension was also tested. Within- and across-patient differences in the distribution of deficits induced by ECM were modeled statistically using the recently developed method of Template Mixture Modeling. Cortical representations of auditory discrimination were smaller, more localized, and less variable across subjects than auditory comprehension. Stimulus effects were observed only for speech-tone contrasts. When tasks and stimuli were held constant, two auditory discrimination centers were identified in the posterior temporal lobe. There was also an interaction between task and intersubject effects, with more intersubject variability in cortical maps of auditory comprehension than auditory discrimination. These results demonstrate the utility of using the statistical modeling approach of Template Mixture Modeling to quantify sources of variability in cortical functional organization.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 382-387 |
| Number of pages | 6 |
| Journal | Experimental Brain Research |
| Volume | 153 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 2003 |
| Externally published | Yes |
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Keywords
- Brain mapping
- Electrocortical mapping
- Speech perception
- Statistical modeling
- Template mixture modeling
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Modeling variability in cortical representations of human complex sound perception. / Miglioretti, Diana L; Boatman, D.
In: Experimental Brain Research, Vol. 153, No. 3, 12.2003, p. 382-387.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modeling variability in cortical representations of human complex sound perception
AU - Miglioretti, Diana L
AU - Boatman, D.
PY - 2003/12
Y1 - 2003/12
N2 - This study investigated methodological (task, stimulus) and intersubject variability in the cortical representation of auditory processing of complex sounds, including speech. Subjects were adult seizure patients undergoing left hemisphere electrocortical mapping (ECM). We tested auditory discrimination of complex sounds, including frequency-modulated tones and speech syllables (digitized, synthesized) contrasted by phonetic features and lexical status. To measure task effects, auditory comprehension was also tested. Within- and across-patient differences in the distribution of deficits induced by ECM were modeled statistically using the recently developed method of Template Mixture Modeling. Cortical representations of auditory discrimination were smaller, more localized, and less variable across subjects than auditory comprehension. Stimulus effects were observed only for speech-tone contrasts. When tasks and stimuli were held constant, two auditory discrimination centers were identified in the posterior temporal lobe. There was also an interaction between task and intersubject effects, with more intersubject variability in cortical maps of auditory comprehension than auditory discrimination. These results demonstrate the utility of using the statistical modeling approach of Template Mixture Modeling to quantify sources of variability in cortical functional organization.
AB - This study investigated methodological (task, stimulus) and intersubject variability in the cortical representation of auditory processing of complex sounds, including speech. Subjects were adult seizure patients undergoing left hemisphere electrocortical mapping (ECM). We tested auditory discrimination of complex sounds, including frequency-modulated tones and speech syllables (digitized, synthesized) contrasted by phonetic features and lexical status. To measure task effects, auditory comprehension was also tested. Within- and across-patient differences in the distribution of deficits induced by ECM were modeled statistically using the recently developed method of Template Mixture Modeling. Cortical representations of auditory discrimination were smaller, more localized, and less variable across subjects than auditory comprehension. Stimulus effects were observed only for speech-tone contrasts. When tasks and stimuli were held constant, two auditory discrimination centers were identified in the posterior temporal lobe. There was also an interaction between task and intersubject effects, with more intersubject variability in cortical maps of auditory comprehension than auditory discrimination. These results demonstrate the utility of using the statistical modeling approach of Template Mixture Modeling to quantify sources of variability in cortical functional organization.
KW - Brain mapping
KW - Electrocortical mapping
KW - Speech perception
KW - Statistical modeling
KW - Template mixture modeling
UR - http://www.scopus.com/inward/record.url?scp=0344873308&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0344873308&partnerID=8YFLogxK
U2 - 10.1007/s00221-003-1703-2
DO - 10.1007/s00221-003-1703-2
M3 - Article
C2 - 14534769
AN - SCOPUS:0344873308
VL - 153
SP - 382
EP - 387
JO - Experimental Brain Research
JF - Experimental Brain Research
SN - 0014-4819
IS - 3
ER -