Modeling the isolated cardiac myocyte

Jose L. Puglisi, Fei Wang, Donald M Bers

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Computer modeling of cardiac myocytes has flourished in recent years. Models have evolved from mathematical descriptions of ionic channels alone to more sophisticated formulations that include calcium transport mechanisms, ATP production and metabolic pathways. The increased complexity is fueled by the new data available in the field. The continuous production of experimental data has led to the evolution of increasingly refined descriptions of the phenomena by modelers. Integrating the numerous systems involved in cardiac myocyte homeostasis makes the use of computer models necessary due to the unreliability of intuitive approaches. However the complexity of the model should not imply a cumbersome operation of the program. As with any tool, computer models have to be easy to operate or their strength will be diminished and potential users will not benefit fully from them. The contribution of the computer modeler to their respective biological fields will be more successful and enduring if modelers devote sufficient time to implement their equations into a model with user-friendly characteristics.

Original languageEnglish (US)
Pages (from-to)163-178
Number of pages16
JournalProgress in Biophysics and Molecular Biology
Volume85
Issue number2-3
DOIs
StatePublished - Jun 2004
Externally publishedYes

Keywords

  • Cardiac
  • Modeling
  • Myocyte

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics

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