Modeling the human ventricular myocyte

Jose L. Puglisi, Salah Wajeeh, Fei Wang, Donald M Bers

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

During space flight, the heart is exposed to conditions that place its function at risk. These risks involve alterations to the cardiac mechanical and electrical function including ventricular atrophy and arrhythmias. A mathematical model is essential to predict impaired responses, evaluate their danger and develop countermeasures. To properly simulate an astronaut's heart it is important to have a reliable and accurate model of the human cardiac cell. We built a computer program that simulates the human cardiac myocyte. It incorporates the latest experimental findings in ionic currents, excitation-contraction coupling, calcium dynamics and force generation. The program can be easily customized for different regions of the heart and can take into account the heterogeneity of the ventricular wall.

Original languageEnglish (US)
Title of host publicationInternational Astronautical Federation - 55th International Astronautical Congress 2004
Pages1276-1277
Number of pages2
Volume2
StatePublished - 2004
Externally publishedYes
EventInternational Astronautical Federation - 55th International Astronautical Congress 2004 - Vancouver, Canada
Duration: Oct 4 2004Oct 8 2004

Other

OtherInternational Astronautical Federation - 55th International Astronautical Congress 2004
CountryCanada
CityVancouver
Period10/4/0410/8/04

ASJC Scopus subject areas

  • Aerospace Engineering
  • Space and Planetary Science

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  • Cite this

    Puglisi, J. L., Wajeeh, S., Wang, F., & Bers, D. M. (2004). Modeling the human ventricular myocyte. In International Astronautical Federation - 55th International Astronautical Congress 2004 (Vol. 2, pp. 1276-1277)