Modeling particle deposition in extrathoracic airways

R. Sarangapani, A. S. Wexler

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The extrathoracic (ET) airways filter, warm, and humidify the inspired air and provide olfactory function. These multiple functions are reflected in its complex anatomy and physiology. The ET airways form the first line of defense against inhaled pollutants, both gaseous as well as particulate. To accurately assess the risk posed by inhaled particulate matter to the lung, it is essential to understand the filtering efficiency of the ET airways. In this paper computational fluid dynamics is used to simulate the airflow patterns and the thermodynamics of the ET airways. We detail the procedure to develop a computer reconstruction of the ET airways and the computer model to simulate the flow variable. Using this information we compute the particle trajectories, for both hygroscopic and nonhygroscopic aerosols, and use this data to evaluate the particle deposition pattern in the ET airways. The model predicts high relative humidity conditions in the ET airways. The model also shows that the high relative humidity conditions are conducive for rapid growth of hygroscopic particles and dramatically alter the deposition characteristics of ambient (hygroscopic) aerosol.

Original languageEnglish (US)
Pages (from-to)72-89
Number of pages18
JournalAerosol Science and Technology
Volume32
Issue number1
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

relative humidity
aerosol
modeling
computational fluid dynamics
anatomy
airflow
physiology
Aerosols
particulate matter
Particles (particulate matter)
thermodynamics
trajectory
Atmospheric humidity
filter
pollutant
air
Particulate Matter
Physiology
particle
Computational fluid dynamics

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Mechanical Engineering

Cite this

Modeling particle deposition in extrathoracic airways. / Sarangapani, R.; Wexler, A. S.

In: Aerosol Science and Technology, Vol. 32, No. 1, 2000, p. 72-89.

Research output: Contribution to journalArticle

Sarangapani, R. ; Wexler, A. S. / Modeling particle deposition in extrathoracic airways. In: Aerosol Science and Technology. 2000 ; Vol. 32, No. 1. pp. 72-89.
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