Abstract
We report on modeling and bench test results targeted at better understanding of valved glaucoma drainage devices (GDDs), a common current surgical treatment for glaucoma. A simple equivalent circuit is described to model fluid mechanical behavior of the aqueous humor in an eye with glaucoma, both before and after implantation of a valved GDD. Finite element method simulations (FEM), based on the lubrication-von Kármán model, are then performed to analyze the valve's mechanical and fluidic performance. Using nanoporous membranes to mimic the in vivo fibrous capsule, we have developed a microfluidic bench test to simulate the aqueous humor flow and the post-implantation fibrous tissue encapsulation around the GDD back plate. Our numerical and bench test results show that, contrary to the prevailing belief, the valve significantly contributes to the total pressure drop even after fibrous capsule formation. Furthermore, we show that bypassing the valve through a simple polyimide tube insertion will dramatically lower the intraocular pressure (IOP) after fibrous capsule formation. This may offer a new treatment option in some patients with advanced glaucoma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 948-951 |
| Number of pages | 4 |
| Journal | IEEE Transactions on Biomedical Engineering |
| Volume | 52 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2005 |
| Externally published | Yes |
Fingerprint
Keywords
- Ahmed Glaucoma Valve™
- Glaucoma
- Glaucoma drainage device
- Microfluidic
- Modeling
ASJC Scopus subject areas
- Biomedical Engineering
Cite this
Modeling and characterization of a valved glaucoma drainage device with implications for enhanced therapeutic efficacy. / Pan, Tingrui; Stay, Matthew S.; Barocas, Victor H.; Brown, J. David; Ziaie, Babak.
In: IEEE Transactions on Biomedical Engineering, Vol. 52, No. 5, 01.05.2005, p. 948-951.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modeling and characterization of a valved glaucoma drainage device with implications for enhanced therapeutic efficacy
AU - Pan, Tingrui
AU - Stay, Matthew S.
AU - Barocas, Victor H.
AU - Brown, J. David
AU - Ziaie, Babak
PY - 2005/5/1
Y1 - 2005/5/1
N2 - We report on modeling and bench test results targeted at better understanding of valved glaucoma drainage devices (GDDs), a common current surgical treatment for glaucoma. A simple equivalent circuit is described to model fluid mechanical behavior of the aqueous humor in an eye with glaucoma, both before and after implantation of a valved GDD. Finite element method simulations (FEM), based on the lubrication-von Kármán model, are then performed to analyze the valve's mechanical and fluidic performance. Using nanoporous membranes to mimic the in vivo fibrous capsule, we have developed a microfluidic bench test to simulate the aqueous humor flow and the post-implantation fibrous tissue encapsulation around the GDD back plate. Our numerical and bench test results show that, contrary to the prevailing belief, the valve significantly contributes to the total pressure drop even after fibrous capsule formation. Furthermore, we show that bypassing the valve through a simple polyimide tube insertion will dramatically lower the intraocular pressure (IOP) after fibrous capsule formation. This may offer a new treatment option in some patients with advanced glaucoma.
AB - We report on modeling and bench test results targeted at better understanding of valved glaucoma drainage devices (GDDs), a common current surgical treatment for glaucoma. A simple equivalent circuit is described to model fluid mechanical behavior of the aqueous humor in an eye with glaucoma, both before and after implantation of a valved GDD. Finite element method simulations (FEM), based on the lubrication-von Kármán model, are then performed to analyze the valve's mechanical and fluidic performance. Using nanoporous membranes to mimic the in vivo fibrous capsule, we have developed a microfluidic bench test to simulate the aqueous humor flow and the post-implantation fibrous tissue encapsulation around the GDD back plate. Our numerical and bench test results show that, contrary to the prevailing belief, the valve significantly contributes to the total pressure drop even after fibrous capsule formation. Furthermore, we show that bypassing the valve through a simple polyimide tube insertion will dramatically lower the intraocular pressure (IOP) after fibrous capsule formation. This may offer a new treatment option in some patients with advanced glaucoma.
KW - Ahmed Glaucoma Valve™
KW - Glaucoma
KW - Glaucoma drainage device
KW - Microfluidic
KW - Modeling
UR - http://www.scopus.com/inward/record.url?scp=18744381850&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18744381850&partnerID=8YFLogxK
U2 - 10.1109/TBME.2005.845222
DO - 10.1109/TBME.2005.845222
M3 - Article
C2 - 15887547
AN - SCOPUS:18744381850
VL - 52
SP - 948
EP - 951
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
SN - 0018-9294
IS - 5
ER -