Model Systems for Addressing Mechanism of Arrhythmogenesis in Cardiac Repair

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: Cardiac cell-based therapy represents a promising approach for cardiac repair. However, one of the main challenges is cardiac arrhythmias associated with stem cell transplantation. The current review summarizes the recent progress in model systems for addressing mechanisms of arrhythmogenesis in cardiac repair. Recent Findings: Animal models have been extensively developed for mechanistic studies of cardiac arrhythmogenesis. Advances in human induced pluripotent stem cells (hiPSCs), patient-specific disease models, tissue engineering, and gene editing have greatly enhanced our ability to probe the mechanistic bases of cardiac arrhythmias. Additionally, recent development in multiscale computational studies and machine learning provides yet another powerful tool to quantitatively decipher the mechanisms of cardiac arrhythmias. Summary: Advancing efforts towards the integrations of experimental and computational studies are critical to gain insights into novel mitigation strategies for cardiac arrhythmias in cell-based therapy.

Original languageEnglish (US)
Article number72
JournalCurrent Cardiology Reports
Volume23
Issue number6
DOIs
StatePublished - Jun 2021

Keywords

  • Animal models of cardiac arrhythmias
  • Cardiac arrhythmias
  • Cardiac cell-based therapy
  • Cardiac hypertrophy
  • Genome editing
  • Heart failure
  • Human-induced pluripotent stem cells
  • Patient-specific disease models

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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