Mode of Delivery Is Associated With Asthma and Allergy Occurrences in Children

Muhammad T. Salam, Helene G Margolis, Rob McConnell, James A. McGregor, Edward L. Avol, Frank D. Gilliland

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Purpose: A growing body of evidence indicates that perinatal factors modulate immune development and thereby may affect childhood asthma risk. In this study, we examined the associations between birth by cesarean section (C-section) and atopic disease occurrence in childhood. Methods: Subjects were born in California between 1975 and 1987 and were 8 to 17 years old during their enrollment in the Children's Health Study. Our analysis was restricted to 3464 children born at or after 37 weeks of gestation with a birth weight of 2500 g or greater based on birth certificate data. Information about sociodemographic factors, reported physician-diagnosed asthma, and other atopic diseases was obtained by using a self-administered structured questionnaire. Logistic regression models were fitted to compute odds ratios (ORs) and 95% confidence intervals (CIs). Results: Children born by C-section were at increased risk for asthma (OR, 1.33; 95% CI, 1.01-1.75), hay fever (OR, 1.57; 95% CI, 1.24-1.99), and allergy (OR, 1.26; 95% CI, 1.03-1.53) compared with those born vaginally. Risk associated with C-section was the same for children regardless of family history of asthma or allergy. Conclusion: We conclude that birth by C-section or processes associated with it may increase the risk for atopic disease in childhood.

Original languageEnglish (US)
Pages (from-to)341-346
Number of pages6
JournalAnnals of Epidemiology
Volume16
Issue number5
DOIs
StatePublished - May 2006
Externally publishedYes

Fingerprint

Cesarean Section
Hypersensitivity
Asthma
Odds Ratio
Confidence Intervals
Logistic Models
Parturition
Birth Certificates
Seasonal Allergic Rhinitis
Immunologic Factors
Birth Weight
Physicians
Pregnancy

Keywords

  • Allergy
  • Asthma
  • Cesarean Section
  • Hay Fever
  • Mode of Delivery

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

Mode of Delivery Is Associated With Asthma and Allergy Occurrences in Children. / Salam, Muhammad T.; Margolis, Helene G; McConnell, Rob; McGregor, James A.; Avol, Edward L.; Gilliland, Frank D.

In: Annals of Epidemiology, Vol. 16, No. 5, 05.2006, p. 341-346.

Research output: Contribution to journalArticle

Salam, Muhammad T. ; Margolis, Helene G ; McConnell, Rob ; McGregor, James A. ; Avol, Edward L. ; Gilliland, Frank D. / Mode of Delivery Is Associated With Asthma and Allergy Occurrences in Children. In: Annals of Epidemiology. 2006 ; Vol. 16, No. 5. pp. 341-346.
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