Modafinil modulation of the default mode network

Michael J. Minzenberg, Jong H. Yoon, Cameron S Carter

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Rationale: The default mode network (DMN) is a functional network which is implicated in a range of cognitive processes. This network is proposed to consist of hubs located in the ventromedial prefrontal cortex (vmPFC), posterior cingulate/retrosplenial cortex (PCC/rSpl), and inferior parietal lobule (IPL), with other midline cortical and temporal lobe nodes connected to these hubs. How this network is modulated by neurochemical systems during functional brain activity is not yet understood. Objectives: In the present study, we used the norepinephrine/dopamine transporter inhibitor modafinil to test the hypothesis that this drug modulates the DMN. Methods: Eighteen healthy right-handed adults participated in a double-blind, placebo-controlled study of single oral dose modafinil 200 mg. They performed a simple visual sensorimotor task during slow event-related fMRI. Drug effects were interrogated within the DMN defined by task-induced deactivation (TID) on placebo. Results: There was a trend toward faster reaction time (RT) on modafinil (Cohen's d∈=∈0.38). Brain regions within the DMN which exhibited significant modafinil-induced augmentation of TID included vmPFC, PCC/rSpl, and left IPL. Across subjects, the modafinil effect on TID in the vmPFC was significantly and specifically associated with drug effects on RT speeding. Conclusions: Modafinil augments TID in the DMN to facilitate sensorimotor processing speed, an effect which may be particularly dependent on changes in vmPFC activity. This is consistent with the gain control function of catecholamine systems and may represent an important aspect of the pro-cognitive effects of modafinil.

Original languageEnglish (US)
Pages (from-to)23-31
Number of pages9
JournalPsychopharmacology
Volume215
Issue number1
DOIs
StatePublished - May 2011

Fingerprint

Prefrontal Cortex
Parietal Lobe
Gyrus Cinguli
Placebos
Pharmaceutical Preparations
Norepinephrine Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins
Brain
Temporal Lobe
modafinil
Catecholamines
Magnetic Resonance Imaging

Keywords

  • Catecholamines
  • Default mode network
  • Gain control
  • Modafinil
  • Negative BOLD response
  • Task-induced deactivation

ASJC Scopus subject areas

  • Pharmacology

Cite this

Modafinil modulation of the default mode network. / Minzenberg, Michael J.; Yoon, Jong H.; Carter, Cameron S.

In: Psychopharmacology, Vol. 215, No. 1, 05.2011, p. 23-31.

Research output: Contribution to journalArticle

Minzenberg, Michael J. ; Yoon, Jong H. ; Carter, Cameron S. / Modafinil modulation of the default mode network. In: Psychopharmacology. 2011 ; Vol. 215, No. 1. pp. 23-31.
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