Modafinil effects on middle-frequency oscillatory power during rule selection in schizophrenia

Michael Mizenberg, Jong Yoon, Yaoan Cheng, Cameron S. Carter

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Control-related cognitive processes such as rule selection are associated with cortical oscillations in the theta, alpha and, beta ranges, and modulated by catecholamine neurotransmission. Thus, a potential strategy for improving cognitive control deficits in schizophrenia would be to use pro-catecholamine pharmacological agents to augment these control-related oscillations. In a double-blind, placebo-controlled (within-subjects) study, we tested the effects of adjunctive single-dose modafinil 200 mg on rule-related 4-30 Hz oscillations in 23 stable schizophrenia patients, using EEG during cognitive control task performance. EEG data underwent time-frequency decomposition with Morlet wavelets to determine the power of 4-30 Hz oscillations. Modafinil (relative to placebo) enhanced oscillatory power associated with high-control rule selection in theta, alpha, and beta ranges, with modest effects during rule maintenance. Modafinil treatment in schizophrenia augments middle-frequency cortical oscillatory power associated with rule selection, and may subserve diverse subcomponent processes in proactive cognitive control.

Original languageEnglish (US)
Pages (from-to)3018-3026
Number of pages9
JournalNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Issue number13
StatePublished - Dec 1 2014

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health


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