Modafinil augments oscillatory power in middle frequencies during rule selection

Michael Mizenberg, Glenn C. Gomes, Jong Yoon, Andrew J. Watrous, Joy Geng, Alana J. Firl, Cameron S. Carter

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Control-related cognitive processes are associated with cortical oscillations and modulated by catecholamine neurotransmitters. It remains unclear how catecholamine systems modulate control-related oscillations. We tested modafinil effects on rule-related 4-30Hz oscillations, with double-blind, placebo-controlled (within-subjects) testing of 22 healthy adults, using EEG during cognitive control task performance. EEG data underwent time-frequency decomposition with Morlet wavelets to determine power of 4-30Hz oscillations. Modafinil enhanced oscillatory power associated with high-control rule selection in theta, alpha, and beta ranges, with a frontotemporal topography and minimal effects during rule maintenance. Augmentation of catecholamine signaling enhances middle-frequency cortical oscillatory power associated with rule selection, which may subserve diverse subcomponent processes in proactive cognitive control.

Original languageEnglish (US)
Pages (from-to)510-519
Number of pages10
Issue number6
StatePublished - 2014


  • Cognitive control
  • Modafinil
  • Oscillations
  • Prefrontal cortex
  • Rule selection
  • Theta

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology


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