Abstract
Control-related cognitive processes are associated with cortical oscillations and modulated by catecholamine neurotransmitters. It remains unclear how catecholamine systems modulate control-related oscillations. We tested modafinil effects on rule-related 4-30Hz oscillations, with double-blind, placebo-controlled (within-subjects) testing of 22 healthy adults, using EEG during cognitive control task performance. EEG data underwent time-frequency decomposition with Morlet wavelets to determine power of 4-30Hz oscillations. Modafinil enhanced oscillatory power associated with high-control rule selection in theta, alpha, and beta ranges, with a frontotemporal topography and minimal effects during rule maintenance. Augmentation of catecholamine signaling enhances middle-frequency cortical oscillatory power associated with rule selection, which may subserve diverse subcomponent processes in proactive cognitive control.
Original language | English (US) |
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Pages (from-to) | 510-519 |
Number of pages | 10 |
Journal | Psychophysiology |
Volume | 51 |
Issue number | 6 |
DOIs | |
State | Published - 2014 |
Keywords
- Cognitive control
- Modafinil
- Oscillations
- Prefrontal cortex
- Rule selection
- Theta
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
- Experimental and Cognitive Psychology
- Neuropsychology and Physiological Psychology
- Arts and Humanities (miscellaneous)
- Developmental and Educational Psychology