Modafinil augments oscillatory power in middle frequencies during rule selection

Michael Mizenberg; Glenn C. Gomes; Jong Yoon; Andrew J. Watrous; Joy Geng; Alana J. Firl; Cameron S. Carter

doi:10.1111/psyp.12201

Modafinil augments oscillatory power in middle frequencies during rule selection

Michael Mizenberg, Glenn C. Gomes, Jong Yoon, Andrew J. Watrous, Joy Geng, Alana J. Firl, Cameron S. Carter

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Control-related cognitive processes are associated with cortical oscillations and modulated by catecholamine neurotransmitters. It remains unclear how catecholamine systems modulate control-related oscillations. We tested modafinil effects on rule-related 4-30Hz oscillations, with double-blind, placebo-controlled (within-subjects) testing of 22 healthy adults, using EEG during cognitive control task performance. EEG data underwent time-frequency decomposition with Morlet wavelets to determine power of 4-30Hz oscillations. Modafinil enhanced oscillatory power associated with high-control rule selection in theta, alpha, and beta ranges, with a frontotemporal topography and minimal effects during rule maintenance. Augmentation of catecholamine signaling enhances middle-frequency cortical oscillatory power associated with rule selection, which may subserve diverse subcomponent processes in proactive cognitive control.

Original language	English (US)
Pages (from-to)	510-519
Number of pages	10
Journal	Psychophysiology
Volume	51
Issue number	6
DOIs	https://doi.org/10.1111/psyp.12201
State	Published - 2014

Keywords

Cognitive control
Modafinil
Oscillations
Prefrontal cortex
Rule selection
Theta

ASJC Scopus subject areas

Physiology
Physiology (medical)
Experimental and Cognitive Psychology
Neuropsychology and Physiological Psychology
Arts and Humanities (miscellaneous)
Developmental and Educational Psychology

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title = "Modafinil augments oscillatory power in middle frequencies during rule selection",

abstract = "Control-related cognitive processes are associated with cortical oscillations and modulated by catecholamine neurotransmitters. It remains unclear how catecholamine systems modulate control-related oscillations. We tested modafinil effects on rule-related 4-30Hz oscillations, with double-blind, placebo-controlled (within-subjects) testing of 22 healthy adults, using EEG during cognitive control task performance. EEG data underwent time-frequency decomposition with Morlet wavelets to determine power of 4-30Hz oscillations. Modafinil enhanced oscillatory power associated with high-control rule selection in theta, alpha, and beta ranges, with a frontotemporal topography and minimal effects during rule maintenance. Augmentation of catecholamine signaling enhances middle-frequency cortical oscillatory power associated with rule selection, which may subserve diverse subcomponent processes in proactive cognitive control.",

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AU - Gomes, Glenn C.

AU - Yoon, Jong

AU - Watrous, Andrew J.

AU - Geng, Joy

AU - Firl, Alana J.

AU - Carter, Cameron S.

PY - 2014

Y1 - 2014

N2 - Control-related cognitive processes are associated with cortical oscillations and modulated by catecholamine neurotransmitters. It remains unclear how catecholamine systems modulate control-related oscillations. We tested modafinil effects on rule-related 4-30Hz oscillations, with double-blind, placebo-controlled (within-subjects) testing of 22 healthy adults, using EEG during cognitive control task performance. EEG data underwent time-frequency decomposition with Morlet wavelets to determine power of 4-30Hz oscillations. Modafinil enhanced oscillatory power associated with high-control rule selection in theta, alpha, and beta ranges, with a frontotemporal topography and minimal effects during rule maintenance. Augmentation of catecholamine signaling enhances middle-frequency cortical oscillatory power associated with rule selection, which may subserve diverse subcomponent processes in proactive cognitive control.

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Modafinil augments oscillatory power in middle frequencies during rule selection

Abstract

Keywords

ASJC Scopus subject areas

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