Modafinil augments oscillatory power in middle frequencies during rule selection

Michael J. Minzenberg, Glenn C. Gomes, Jong H. Yoon, Andrew J. Watrous, Joy Geng, Alana J. Firl, Cameron S Carter

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Control-related cognitive processes are associated with cortical oscillations and modulated by catecholamine neurotransmitters. It remains unclear how catecholamine systems modulate control-related oscillations. We tested modafinil effects on rule-related 4-30Hz oscillations, with double-blind, placebo-controlled (within-subjects) testing of 22 healthy adults, using EEG during cognitive control task performance. EEG data underwent time-frequency decomposition with Morlet wavelets to determine power of 4-30Hz oscillations. Modafinil enhanced oscillatory power associated with high-control rule selection in theta, alpha, and beta ranges, with a frontotemporal topography and minimal effects during rule maintenance. Augmentation of catecholamine signaling enhances middle-frequency cortical oscillatory power associated with rule selection, which may subserve diverse subcomponent processes in proactive cognitive control.

Original languageEnglish (US)
Pages (from-to)510-519
Number of pages10
JournalPsychophysiology
Volume51
Issue number6
DOIs
StatePublished - 2014

Fingerprint

Catecholamines
Electroencephalography
Task Performance and Analysis
Neurotransmitter Agents
Placebos
Maintenance
Power (Psychology)
modafinil
Oscillation
Electroencephalogram
Cognitive Control

Keywords

  • Cognitive control
  • Modafinil
  • Oscillations
  • Prefrontal cortex
  • Rule selection
  • Theta

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

Cite this

Minzenberg, M. J., Gomes, G. C., Yoon, J. H., Watrous, A. J., Geng, J., Firl, A. J., & Carter, C. S. (2014). Modafinil augments oscillatory power in middle frequencies during rule selection. Psychophysiology, 51(6), 510-519. https://doi.org/10.1111/psyp.12201

Modafinil augments oscillatory power in middle frequencies during rule selection. / Minzenberg, Michael J.; Gomes, Glenn C.; Yoon, Jong H.; Watrous, Andrew J.; Geng, Joy; Firl, Alana J.; Carter, Cameron S.

In: Psychophysiology, Vol. 51, No. 6, 2014, p. 510-519.

Research output: Contribution to journalArticle

Minzenberg, MJ, Gomes, GC, Yoon, JH, Watrous, AJ, Geng, J, Firl, AJ & Carter, CS 2014, 'Modafinil augments oscillatory power in middle frequencies during rule selection', Psychophysiology, vol. 51, no. 6, pp. 510-519. https://doi.org/10.1111/psyp.12201
Minzenberg MJ, Gomes GC, Yoon JH, Watrous AJ, Geng J, Firl AJ et al. Modafinil augments oscillatory power in middle frequencies during rule selection. Psychophysiology. 2014;51(6):510-519. https://doi.org/10.1111/psyp.12201
Minzenberg, Michael J. ; Gomes, Glenn C. ; Yoon, Jong H. ; Watrous, Andrew J. ; Geng, Joy ; Firl, Alana J. ; Carter, Cameron S. / Modafinil augments oscillatory power in middle frequencies during rule selection. In: Psychophysiology. 2014 ; Vol. 51, No. 6. pp. 510-519.
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