MMTV-like env gene sequences in human breast cancer

Y. Wang, I. Pelisson, S. M. Melana, Vera S Go, J. F. Holland, B. G T Pogo

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

We have previously detected an MMTV env gene-like 660 bp sequence in 38% of human breast cancers, but not in normal tissues or other tumors. In this communication we report the sequences from eleven tumors and three breast cancer cell lines, and compare them to four strains of MMTV and to the known endogenous retroviral sequences. The breast cancer sequences were highly homogenous to the MMTV's, but not to the endogenous sequences suggesting an exogenous origin.

Original languageEnglish (US)
Pages (from-to)171-180
Number of pages10
JournalArchives of Virology
Volume146
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Applied Microbiology and Biotechnology

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    Wang, Y., Pelisson, I., Melana, S. M., Go, V. S., Holland, J. F., & Pogo, B. G. T. (2001). MMTV-like env gene sequences in human breast cancer. Archives of Virology, 146(1), 171-180. https://doi.org/10.1007/s007050170201