Abstract
Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer. MKP1 expression is inducible in radiation-treated breast cancer cells, and correlates with human epidermal growth factor receptor 2 (ERBB2, HER2) expression. The role of MKP1 in therapy resistance suggests that targeting MKP1 in HER2-positive breast tumors may significantly enhance the efficacy of anti-HER2 and other anticancer therapies.
| Original language | English (US) |
|---|---|
| Article number | e997518 |
| Journal | Molecular and Cellular Oncology |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2 2015 |
Keywords
- breast cancer
- HER2
- mitochondria
- MKP1
- radioresistance
ASJC Scopus subject areas
- Cancer Research
- Molecular Medicine
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Cite this
Candas, D., & Li, J-J. (2015). MKP1 mediates resistance to therapy in HER2-positive breast tumors. Molecular and Cellular Oncology, 2(4), [e997518]. https://doi.org/10.1080/23723556.2014.997518