Abstract
Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer. MKP1 expression is inducible in radiation-treated breast cancer cells, and correlates with human epidermal growth factor receptor 2 (ERBB2, HER2) expression. The role of MKP1 in therapy resistance suggests that targeting MKP1 in HER2-positive breast tumors may significantly enhance the efficacy of anti-HER2 and other anticancer therapies.
| Original language | English (US) |
|---|---|
| Article number | e997518 |
| Journal | Molecular and Cellular Oncology |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2 2015 |
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Keywords
- breast cancer
- HER2
- mitochondria
- MKP1
- radioresistance
ASJC Scopus subject areas
- Cancer Research
- Molecular Medicine
Cite this
MKP1 mediates resistance to therapy in HER2-positive breast tumors. / Candas, Demet; Li, Jian-Jian.
In: Molecular and Cellular Oncology, Vol. 2, No. 4, e997518, 02.10.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - MKP1 mediates resistance to therapy in HER2-positive breast tumors
AU - Candas, Demet
AU - Li, Jian-Jian
PY - 2015/10/2
Y1 - 2015/10/2
N2 - Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer. MKP1 expression is inducible in radiation-treated breast cancer cells, and correlates with human epidermal growth factor receptor 2 (ERBB2, HER2) expression. The role of MKP1 in therapy resistance suggests that targeting MKP1 in HER2-positive breast tumors may significantly enhance the efficacy of anti-HER2 and other anticancer therapies.
AB - Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer. MKP1 expression is inducible in radiation-treated breast cancer cells, and correlates with human epidermal growth factor receptor 2 (ERBB2, HER2) expression. The role of MKP1 in therapy resistance suggests that targeting MKP1 in HER2-positive breast tumors may significantly enhance the efficacy of anti-HER2 and other anticancer therapies.
KW - breast cancer
KW - HER2
KW - mitochondria
KW - MKP1
KW - radioresistance
UR - http://www.scopus.com/inward/record.url?scp=85034048660&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85034048660&partnerID=8YFLogxK
U2 - 10.1080/23723556.2014.997518
DO - 10.1080/23723556.2014.997518
M3 - Article
AN - SCOPUS:85034048660
VL - 2
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
SN - 2372-3556
IS - 4
M1 - e997518
ER -