MKP1 mediates resistance to therapy in HER2-positive breast tumors

Demet Candas, Jian-Jian Li

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer. MKP1 expression is inducible in radiation-treated breast cancer cells, and correlates with human epidermal growth factor receptor 2 (ERBB2, HER2) expression. The role of MKP1 in therapy resistance suggests that targeting MKP1 in HER2-positive breast tumors may significantly enhance the efficacy of anti-HER2 and other anticancer therapies.

Original languageEnglish (US)
Article numbere997518
JournalMolecular and Cellular Oncology
Volume2
Issue number4
DOIs
StatePublished - Oct 2 2015

Keywords

  • breast cancer
  • HER2
  • mitochondria
  • MKP1
  • radioresistance

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

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