MKP1 mediates resistance to therapy in HER2-positive breast tumors

Demet Candas; Jian-Jian Li

doi:10.1080/23723556.2014.997518

MKP1 mediates resistance to therapy in HER2-positive breast tumors

Demet Candas, Jian-Jian Li

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer. MKP1 expression is inducible in radiation-treated breast cancer cells, and correlates with human epidermal growth factor receptor 2 (ERBB2, HER2) expression. The role of MKP1 in therapy resistance suggests that targeting MKP1 in HER2-positive breast tumors may significantly enhance the efficacy of anti-HER2 and other anticancer therapies.

Original language	English (US)
Article number	e997518
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2014.997518
State	Published - Oct 2 2015

Keywords

breast cancer
HER2
mitochondria
MKP1
radioresistance

ASJC Scopus subject areas

Cancer Research
Molecular Medicine

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title = "MKP1 mediates resistance to therapy in HER2-positive breast tumors",

abstract = "Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer. MKP1 expression is inducible in radiation-treated breast cancer cells, and correlates with human epidermal growth factor receptor 2 (ERBB2, HER2) expression. The role of MKP1 in therapy resistance suggests that targeting MKP1 in HER2-positive breast tumors may significantly enhance the efficacy of anti-HER2 and other anticancer therapies.",

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AU - Li, Jian-Jian

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AB - Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer. MKP1 expression is inducible in radiation-treated breast cancer cells, and correlates with human epidermal growth factor receptor 2 (ERBB2, HER2) expression. The role of MKP1 in therapy resistance suggests that targeting MKP1 in HER2-positive breast tumors may significantly enhance the efficacy of anti-HER2 and other anticancer therapies.

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KW - HER2

KW - mitochondria

KW - MKP1

KW - radioresistance

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MKP1 mediates resistance to therapy in HER2-positive breast tumors

Abstract

Keywords

ASJC Scopus subject areas

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