Abstract
Middle cerebral artery (MCA) occlusion in rats induced c-fos and junB mRNA later in all ipsilateral cortex outside the MCA distribution and in many subcortical structures: medial striatum; most of thalamus including medial and lateral geniculate nuclei; substantia nigra; and hippocampus. The N-methyl-d-aspartate (NMDA) antagonist, MK-801 (4 mg/kg, i.p.) inhibited c-fos and junB mRNA induction in the cortex, striatum, thalamus, and hippocampus but not in the substantia nigra. These data show that c-fos and junB mRNA induction in cortex, striatum, thalamus, hippocampus involves the activation of NMDA receptors whereas different receptors must be implicated in the induction in substantia nigra.
Original language | English (US) |
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Pages (from-to) | 111-114 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 179 |
Issue number | 1-2 |
DOIs | |
State | Published - Sep 26 1994 |
Externally published | Yes |
Keywords
- Brain
- c-fos
- Focal cerebral ischemia
- junB
- N-Methyl-d-aspartate
- NMDA
- Stroke
ASJC Scopus subject areas
- Neuroscience(all)