MK-801 inhibits the induction of immediate early genes in cerebral cortex, thalamus, and hippocampus, but not in substantia nigra following middle cerebral artery occlusion

Hiroyuki Kinouchi; Frank R Sharp; Pak H. Chan; Shigeki Mikawa; Hideyuki Kamii; Shouichi Arai; Takashi Yoshimoto

doi:10.1016/0304-3940(94)90947-4

MK-801 inhibits the induction of immediate early genes in cerebral cortex, thalamus, and hippocampus, but not in substantia nigra following middle cerebral artery occlusion

Hiroyuki Kinouchi, Frank R Sharp, Pak H. Chan, Shigeki Mikawa, Hideyuki Kamii, Shouichi Arai, Takashi Yoshimoto

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Middle cerebral artery (MCA) occlusion in rats induced c-fos and junB mRNA later in all ipsilateral cortex outside the MCA distribution and in many subcortical structures: medial striatum; most of thalamus including medial and lateral geniculate nuclei; substantia nigra; and hippocampus. The N-methyl-d-aspartate (NMDA) antagonist, MK-801 (4 mg/kg, i.p.) inhibited c-fos and junB mRNA induction in the cortex, striatum, thalamus, and hippocampus but not in the substantia nigra. These data show that c-fos and junB mRNA induction in cortex, striatum, thalamus, hippocampus involves the activation of NMDA receptors whereas different receptors must be implicated in the induction in substantia nigra.

Original language	English (US)
Pages (from-to)	111-114
Number of pages	4
Journal	Neuroscience Letters
Volume	179
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(94)90947-4
State	Published - Sep 26 1994
Externally published	Yes

Keywords

Brain
c-fos
Focal cerebral ischemia
junB
N-Methyl-d-aspartate
NMDA
Stroke

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/0304-3940(94)90947-4

Fingerprint Dive into the research topics of 'MK-801 inhibits the induction of immediate early genes in cerebral cortex, thalamus, and hippocampus, but not in substantia nigra following middle cerebral artery occlusion'. Together they form a unique fingerprint.

Cite this

MK-801 inhibits the induction of immediate early genes in cerebral cortex, thalamus, and hippocampus, but not in substantia nigra following middle cerebral artery occlusion. / Kinouchi, Hiroyuki; Sharp, Frank R; Chan, Pak H.; Mikawa, Shigeki; Kamii, Hideyuki; Arai, Shouichi; Yoshimoto, Takashi.

In: Neuroscience Letters, Vol. 179, No. 1-2, 26.09.1994, p. 111-114.

Research output: Contribution to journal › Article › peer-review

@article{28a4d53a0e92445c825da4c3feec3eaa,

title = "MK-801 inhibits the induction of immediate early genes in cerebral cortex, thalamus, and hippocampus, but not in substantia nigra following middle cerebral artery occlusion",

abstract = "Middle cerebral artery (MCA) occlusion in rats induced c-fos and junB mRNA later in all ipsilateral cortex outside the MCA distribution and in many subcortical structures: medial striatum; most of thalamus including medial and lateral geniculate nuclei; substantia nigra; and hippocampus. The N-methyl-d-aspartate (NMDA) antagonist, MK-801 (4 mg/kg, i.p.) inhibited c-fos and junB mRNA induction in the cortex, striatum, thalamus, and hippocampus but not in the substantia nigra. These data show that c-fos and junB mRNA induction in cortex, striatum, thalamus, hippocampus involves the activation of NMDA receptors whereas different receptors must be implicated in the induction in substantia nigra.",

keywords = "Brain, c-fos, Focal cerebral ischemia, junB, N-Methyl-d-aspartate, NMDA, Stroke",

author = "Hiroyuki Kinouchi and Sharp, {Frank R} and Chan, {Pak H.} and Shigeki Mikawa and Hideyuki Kamii and Shouichi Arai and Takashi Yoshimoto",

year = "1994",

month = sep,

day = "26",

doi = "10.1016/0304-3940(94)90947-4",

language = "English (US)",

volume = "179",

pages = "111--114",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - MK-801 inhibits the induction of immediate early genes in cerebral cortex, thalamus, and hippocampus, but not in substantia nigra following middle cerebral artery occlusion

AU - Kinouchi, Hiroyuki

AU - Sharp, Frank R

AU - Chan, Pak H.

AU - Mikawa, Shigeki

AU - Kamii, Hideyuki

AU - Arai, Shouichi

AU - Yoshimoto, Takashi

PY - 1994/9/26

Y1 - 1994/9/26

N2 - Middle cerebral artery (MCA) occlusion in rats induced c-fos and junB mRNA later in all ipsilateral cortex outside the MCA distribution and in many subcortical structures: medial striatum; most of thalamus including medial and lateral geniculate nuclei; substantia nigra; and hippocampus. The N-methyl-d-aspartate (NMDA) antagonist, MK-801 (4 mg/kg, i.p.) inhibited c-fos and junB mRNA induction in the cortex, striatum, thalamus, and hippocampus but not in the substantia nigra. These data show that c-fos and junB mRNA induction in cortex, striatum, thalamus, hippocampus involves the activation of NMDA receptors whereas different receptors must be implicated in the induction in substantia nigra.

AB - Middle cerebral artery (MCA) occlusion in rats induced c-fos and junB mRNA later in all ipsilateral cortex outside the MCA distribution and in many subcortical structures: medial striatum; most of thalamus including medial and lateral geniculate nuclei; substantia nigra; and hippocampus. The N-methyl-d-aspartate (NMDA) antagonist, MK-801 (4 mg/kg, i.p.) inhibited c-fos and junB mRNA induction in the cortex, striatum, thalamus, and hippocampus but not in the substantia nigra. These data show that c-fos and junB mRNA induction in cortex, striatum, thalamus, hippocampus involves the activation of NMDA receptors whereas different receptors must be implicated in the induction in substantia nigra.

KW - Brain

KW - c-fos

KW - Focal cerebral ischemia

KW - junB

KW - N-Methyl-d-aspartate

KW - NMDA

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=0028169828&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028169828&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(94)90947-4

DO - 10.1016/0304-3940(94)90947-4

M3 - Article

C2 - 7845604

AN - SCOPUS:0028169828

VL - 179

SP - 111

EP - 114

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -

MK-801 inhibits the induction of immediate early genes in cerebral cortex, thalamus, and hippocampus, but not in substantia nigra following middle cerebral artery occlusion

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this