Mixing, diffusion, and percolation in binary supported membranes containing mixtures of lipids and amphiphilic block copolymers

Douglas L. Gettel, Jeremy Sanborn, Mira A. Patel, Hans Peter De Hoog, Bo Liedberg, Madhavan Nallani, Atul N. Parikh

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Substrate-mediated fusion of small polymersomes, derived from mixtures of lipids and amphiphilic block copolymers, produces hybrid, supported planar bilayers at hydrophilic surfaces, monolayers at hydrophobic surfaces, and binary monolayer/bilayer patterns at amphiphilic surfaces, directly responding to local measures of (and variations in) surface free energy. Despite the large thickness mismatch in their hydrophobic cores, the hybrid membranes do not exhibit microscopic phase separation, reflecting irreversible adsorption and limited lateral reorganization of the polymer component. With increasing fluid-phase lipid fraction, these hybrid, supported membranes undergo a fluidity transition, producing a fully percolating fluid lipid phase beyond a critical area fraction, which matches the percolation threshold for the immobile point obstacles. This then suggests that polymer-lipid hybrid membranes might be useful models for studying obstructed diffusion, such as occurs in lipid membranes containing proteins.

Original languageEnglish (US)
Pages (from-to)10186-10189
Number of pages4
JournalJournal of the American Chemical Society
Volume136
Issue number29
DOIs
StatePublished - Jul 23 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

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    Gettel, D. L., Sanborn, J., Patel, M. A., De Hoog, H. P., Liedberg, B., Nallani, M., & Parikh, A. N. (2014). Mixing, diffusion, and percolation in binary supported membranes containing mixtures of lipids and amphiphilic block copolymers. Journal of the American Chemical Society, 136(29), 10186-10189. https://doi.org/10.1021/ja5037308