Abstract
Herein, we report the use of triisopropyl phosphite (TIP) as an effective substitute for triphenylphosphine in the Mitsunobu reaction of nucleoside analogs. In addition, the use of triphenyl phosphite as an alternative reagent for the expensive hexamethylphosphorous triamide (HMPT) in the Véliz-Beal bromination protocol is reported.
Original language | English (US) |
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Pages (from-to) | 3153-3156 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 47 |
Issue number | 18 |
DOIs | |
State | Published - May 1 2006 |
Externally published | Yes |
Keywords
- Mitsunobu reaction
- Nucleoside analogs
- Phosphites
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery