Mitsunobu reactions of nucleoside analogs using triisopropyl phosphite-DIAD

Eduardo A. Véliz, Peter A. Beal

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Herein, we report the use of triisopropyl phosphite (TIP) as an effective substitute for triphenylphosphine in the Mitsunobu reaction of nucleoside analogs. In addition, the use of triphenyl phosphite as an alternative reagent for the expensive hexamethylphosphorous triamide (HMPT) in the Véliz-Beal bromination protocol is reported.

Original languageEnglish (US)
Pages (from-to)3153-3156
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number18
DOIs
StatePublished - May 1 2006
Externally publishedYes

Keywords

  • Mitsunobu reaction
  • Nucleoside analogs
  • Phosphites

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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