Abstract
Mitosis depends on the mitotic spindle, a subcellular protein machine that uses dynamic microtubules and mitotic motors to assemble itself and to coordinate chromosome movements. Spindle function depends critically on the interplay of microtubule polymer dynamics and the motor proteins and non-motor microtubule-associated proteins (MAPs) that crosslink adjacent microtubules. These microtubule crosslinkers can organize microtubules into bundles with specific polarity patterns and some of them can slide adjacent microtubules in relation to one another. Here, we discuss the functions and mechanisms of action of three such crosslinkers: the motors kinesin-5 and kinesin-14, and the non-motor MAPs of the Ase1p family.
| Original language | English (US) |
|---|---|
| Journal | Current Biology |
| Volume | 19 |
| Issue number | 23 |
| DOIs | |
| State | Published - Dec 15 2009 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Mitotic Microtubule Crosslinkers : Insights from Mechanistic Studies. / Peterman, Erwin J G; Scholey, Jonathan M.
In: Current Biology, Vol. 19, No. 23, 15.12.2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mitotic Microtubule Crosslinkers
T2 - Insights from Mechanistic Studies
AU - Peterman, Erwin J G
AU - Scholey, Jonathan M.
PY - 2009/12/15
Y1 - 2009/12/15
N2 - Mitosis depends on the mitotic spindle, a subcellular protein machine that uses dynamic microtubules and mitotic motors to assemble itself and to coordinate chromosome movements. Spindle function depends critically on the interplay of microtubule polymer dynamics and the motor proteins and non-motor microtubule-associated proteins (MAPs) that crosslink adjacent microtubules. These microtubule crosslinkers can organize microtubules into bundles with specific polarity patterns and some of them can slide adjacent microtubules in relation to one another. Here, we discuss the functions and mechanisms of action of three such crosslinkers: the motors kinesin-5 and kinesin-14, and the non-motor MAPs of the Ase1p family.
AB - Mitosis depends on the mitotic spindle, a subcellular protein machine that uses dynamic microtubules and mitotic motors to assemble itself and to coordinate chromosome movements. Spindle function depends critically on the interplay of microtubule polymer dynamics and the motor proteins and non-motor microtubule-associated proteins (MAPs) that crosslink adjacent microtubules. These microtubule crosslinkers can organize microtubules into bundles with specific polarity patterns and some of them can slide adjacent microtubules in relation to one another. Here, we discuss the functions and mechanisms of action of three such crosslinkers: the motors kinesin-5 and kinesin-14, and the non-motor MAPs of the Ase1p family.
UR - http://www.scopus.com/inward/record.url?scp=71649108346&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=71649108346&partnerID=8YFLogxK
U2 - 10.1016/j.cub.2009.10.047
DO - 10.1016/j.cub.2009.10.047
M3 - Article
C2 - 20064413
AN - SCOPUS:71649108346
VL - 19
JO - Current Biology
JF - Current Biology
SN - 0960-9822
IS - 23
ER -