Abstract
The mitotic spindle uses dynamic microtubules and mitotic motors to generate the pico-Newton scale forces that are needed to drive the mitotic movements that underlie chromosome capture, alignment and segregation. Here, we consider the biophysical and molecular basis of force-generation for chromosome movements in the spindle, and, with reference to the Drosophila embryo mitotic spindle, we briefly discuss how mathematical modeling can complement experimental analysis to illuminate the mechanisms of chromosome-to-pole motility during anaphase A and spindle elongation during anaphase B.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2231-2250 |
| Number of pages | 20 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 67 |
| Issue number | 13 |
| DOIs | |
| State | Published - Jul 2010 |
Fingerprint
Keywords
- Force-generation
- Force-velocity relationships
- Kinesins
- Microtubules
- Mitotic smotors
- Mitotic spindle
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
- Molecular Medicine
- Pharmacology
- Cellular and Molecular Neuroscience
- Medicine(all)
Cite this
Mitotic force generators and chromosome segregation. / Civelekoglu-Scholey, Gul; Scholey, Jonathan M.
In: Cellular and Molecular Life Sciences, Vol. 67, No. 13, 07.2010, p. 2231-2250.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mitotic force generators and chromosome segregation
AU - Civelekoglu-Scholey, Gul
AU - Scholey, Jonathan M.
PY - 2010/7
Y1 - 2010/7
N2 - The mitotic spindle uses dynamic microtubules and mitotic motors to generate the pico-Newton scale forces that are needed to drive the mitotic movements that underlie chromosome capture, alignment and segregation. Here, we consider the biophysical and molecular basis of force-generation for chromosome movements in the spindle, and, with reference to the Drosophila embryo mitotic spindle, we briefly discuss how mathematical modeling can complement experimental analysis to illuminate the mechanisms of chromosome-to-pole motility during anaphase A and spindle elongation during anaphase B.
AB - The mitotic spindle uses dynamic microtubules and mitotic motors to generate the pico-Newton scale forces that are needed to drive the mitotic movements that underlie chromosome capture, alignment and segregation. Here, we consider the biophysical and molecular basis of force-generation for chromosome movements in the spindle, and, with reference to the Drosophila embryo mitotic spindle, we briefly discuss how mathematical modeling can complement experimental analysis to illuminate the mechanisms of chromosome-to-pole motility during anaphase A and spindle elongation during anaphase B.
KW - Force-generation
KW - Force-velocity relationships
KW - Kinesins
KW - Microtubules
KW - Mitotic smotors
KW - Mitotic spindle
UR - http://www.scopus.com/inward/record.url?scp=77954065542&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954065542&partnerID=8YFLogxK
U2 - 10.1007/s00018-010-0326-6
DO - 10.1007/s00018-010-0326-6
M3 - Article
C2 - 20221784
AN - SCOPUS:77954065542
VL - 67
SP - 2231
EP - 2250
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
SN - 1420-682X
IS - 13
ER -