Mitotic force generators and chromosome segregation

Gul Civelekoglu-Scholey; Jonathan M. Scholey

doi:10.1007/s00018-010-0326-6

Mitotic force generators and chromosome segregation

Gul Civelekoglu-Scholey, Jonathan M. Scholey

Molecular and Cellular Biology

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

The mitotic spindle uses dynamic microtubules and mitotic motors to generate the pico-Newton scale forces that are needed to drive the mitotic movements that underlie chromosome capture, alignment and segregation. Here, we consider the biophysical and molecular basis of force-generation for chromosome movements in the spindle, and, with reference to the Drosophila embryo mitotic spindle, we briefly discuss how mathematical modeling can complement experimental analysis to illuminate the mechanisms of chromosome-to-pole motility during anaphase A and spindle elongation during anaphase B.

Original language	English (US)
Pages (from-to)	2231-2250
Number of pages	20
Journal	Cellular and Molecular Life Sciences
Volume	67
Issue number	13
DOIs	https://doi.org/10.1007/s00018-010-0326-6
State	Published - Jul 2010

Keywords

Force-generation
Force-velocity relationships
Kinesins
Microtubules
Mitotic smotors
Mitotic spindle

ASJC Scopus subject areas

Cell Biology
Molecular Biology
Molecular Medicine
Pharmacology
Cellular and Molecular Neuroscience
Medicine(all)

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10.1007/s00018-010-0326-6

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AB - The mitotic spindle uses dynamic microtubules and mitotic motors to generate the pico-Newton scale forces that are needed to drive the mitotic movements that underlie chromosome capture, alignment and segregation. Here, we consider the biophysical and molecular basis of force-generation for chromosome movements in the spindle, and, with reference to the Drosophila embryo mitotic spindle, we briefly discuss how mathematical modeling can complement experimental analysis to illuminate the mechanisms of chromosome-to-pole motility during anaphase A and spindle elongation during anaphase B.

KW - Force-generation

KW - Force-velocity relationships

KW - Kinesins

KW - Microtubules

KW - Mitotic smotors

KW - Mitotic spindle

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Mitotic force generators and chromosome segregation

Abstract

Keywords

ASJC Scopus subject areas

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