Mitotic force generators and chromosome segregation

Gul Civelekoglu-Scholey, Jonathan M. Scholey

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The mitotic spindle uses dynamic microtubules and mitotic motors to generate the pico-Newton scale forces that are needed to drive the mitotic movements that underlie chromosome capture, alignment and segregation. Here, we consider the biophysical and molecular basis of force-generation for chromosome movements in the spindle, and, with reference to the Drosophila embryo mitotic spindle, we briefly discuss how mathematical modeling can complement experimental analysis to illuminate the mechanisms of chromosome-to-pole motility during anaphase A and spindle elongation during anaphase B.

Original languageEnglish (US)
Pages (from-to)2231-2250
Number of pages20
JournalCellular and Molecular Life Sciences
Volume67
Issue number13
DOIs
StatePublished - Jul 2010

Keywords

  • Force-generation
  • Force-velocity relationships
  • Kinesins
  • Microtubules
  • Mitotic smotors
  • Mitotic spindle

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Fingerprint Dive into the research topics of 'Mitotic force generators and chromosome segregation'. Together they form a unique fingerprint.

  • Cite this