Mitochondrial genomes from modern horses reveal the major haplogroups that underwent domestication

Alessandro Achilli, Anna Olivieri, Pedro Soares, Hovirag Lancioni, Baharak Hooshiar Kashani, Ugo A. Perego, Solomon G. Nergadze, Valeria Carossa, Marco Santagostino, Stefano Capomaccio, Michela Felicetti, Walid Al-Achkar, Cecilia Penedo, Andrea Verini-Supplizi, Massoud Houshmand, Scott R. Woodward, Ornella Semino, Maurizio Silvestrelli, Elena Giulotto, Luiśa PereiraHans Jur̈gen Bandelt, Antonio Torroni

Research output: Contribution to journalArticle

127 Scopus citations

Abstract

Archaeological and genetic evidence concerning the time and mode of wild horse (Equus ferus) domestication is still debated. High levels of genetic diversity in horse mtDNA have been detected when analyzing the control region; recurrent mutations, however, tend to blur the structure of the phylogenetic tree. Here, we brought the horse mtDNA phylogeny to the highest level of molecular resolution by analyzing 83 mitochondrial genomes from modern horses across Asia, Europe, the Middle East, and the Americas. Our data reveal 18 major haplogroups (A-R) with radiation times that are mostly confined to the Neolithic and later periods and place the root of the phylogeny corresponding to the Ancestral Mare Mitogenome at ∼130-160 thousand years ago. All haplogroups were detected in modern horses from Asia, but F was only found in E. przewalskii-the only remaining wild horse. Therefore, a wide range of matrilineal lineages from the extinct E. ferus underwent domestication in the Eurasian steppes during the Eneolithic period and were transmitted to modern E. caballus breeds. Importantly, now that the major horse haplogroups have been defined, each with diagnostic mutational motifs (in both the coding and control regions), these haplotypes could be easily used to (i) classify well-preserved ancient remains, (ii) (re)assess the haplogroup variation of modern breeds, including Thoroughbreds, and (iii) evaluate the possible role of mtDNA backgrounds in racehorse performance.

Original languageEnglish (US)
Pages (from-to)2449-2454
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume109
Issue number7
DOIs
StatePublished - Feb 14 2012

Keywords

  • Animal domestication
  • Horse mitochondrial genome
  • mtDNA haplogroups
  • Origin of Equus caballus
  • Przewalski's horse

ASJC Scopus subject areas

  • General

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    Achilli, A., Olivieri, A., Soares, P., Lancioni, H., Kashani, B. H., Perego, U. A., Nergadze, S. G., Carossa, V., Santagostino, M., Capomaccio, S., Felicetti, M., Al-Achkar, W., Penedo, C., Verini-Supplizi, A., Houshmand, M., Woodward, S. R., Semino, O., Silvestrelli, M., Giulotto, E., ... Torroni, A. (2012). Mitochondrial genomes from modern horses reveal the major haplogroups that underwent domestication. Proceedings of the National Academy of Sciences of the United States of America, 109(7), 2449-2454. https://doi.org/10.1073/pnas.1111637109