Mitochondrial form and function

Jonathan R. Friedman, Jodi Nunnari

Research output: Contribution to journalArticle

560 Scopus citations

Abstract

Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells. Owing to their ability to produce ATP through respiration, they became a driving force in evolution. As an essential step in the process of eukaryotic evolution, the size of the mitochondrial chromosome was drastically reduced, and the behaviour of mitochondria within eukaryotic cells radically changed. Recent advances have revealed how the organelle's behaviour has evolved to allow the accurate transmission of its genome and to become responsive to the needs of the cell and its own dysfunction.

Original languageEnglish (US)
Pages (from-to)335-343
Number of pages9
JournalNature
Volume505
Issue number7483
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • General

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    Friedman, J. R., & Nunnari, J. (2014). Mitochondrial form and function. Nature, 505(7483), 335-343. https://doi.org/10.1038/nature12985