Mitochondrial dynamics and heart failure

Anne A Knowlton, T. T. Liu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Mitochondrial dynamics, fission and fusion, were first identified in yeast with investigation in heart cells beginning only in the last 5 to 7 years. In the ensuing time, it has become evident that these processes are not only required for healthy mitochondria, but also, that derangement of these processes contributes to disease. The fission and fusion proteins have a number of functions beyond the mitochondrial dynamics. Many of these functions are related to their membrane activities, such as apoptosis. However, other functions involve other areas of the mitochondria, such as OPA1's role in maintaining cristae structure and preventing cytochrome c leak, and its essential (at least a 10 kDa fragment of OPA1) role in mtDNA replication. In heart disease, changes in expression of these important proteins can have detrimental effects on mitochondrial and cellular function.

Original languageEnglish (US)
Pages (from-to)507-526
Number of pages20
JournalComprehensive Physiology
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Mitochondrial Dynamics
Heart Failure
Mitochondria
Cytochromes c
Mitochondrial DNA
Heart Diseases
Proteins
Yeasts
Apoptosis
Membranes

ASJC Scopus subject areas

  • Medicine(all)
  • Physiology
  • Physiology (medical)

Cite this

Mitochondrial dynamics and heart failure. / Knowlton, Anne A; Liu, T. T.

In: Comprehensive Physiology, Vol. 6, No. 1, 01.01.2016, p. 507-526.

Research output: Contribution to journalArticle

Knowlton, Anne A ; Liu, T. T. / Mitochondrial dynamics and heart failure. In: Comprehensive Physiology. 2016 ; Vol. 6, No. 1. pp. 507-526.
@article{e3ecb0799d83470db80f27d34ad5e2b3,
title = "Mitochondrial dynamics and heart failure",
abstract = "Mitochondrial dynamics, fission and fusion, were first identified in yeast with investigation in heart cells beginning only in the last 5 to 7 years. In the ensuing time, it has become evident that these processes are not only required for healthy mitochondria, but also, that derangement of these processes contributes to disease. The fission and fusion proteins have a number of functions beyond the mitochondrial dynamics. Many of these functions are related to their membrane activities, such as apoptosis. However, other functions involve other areas of the mitochondria, such as OPA1's role in maintaining cristae structure and preventing cytochrome c leak, and its essential (at least a 10 kDa fragment of OPA1) role in mtDNA replication. In heart disease, changes in expression of these important proteins can have detrimental effects on mitochondrial and cellular function.",
author = "Knowlton, {Anne A} and Liu, {T. T.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1002/cphy.c150022",
language = "English (US)",
volume = "6",
pages = "507--526",
journal = "Comprehensive Physiology",
issn = "2040-4603",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Mitochondrial dynamics and heart failure

AU - Knowlton, Anne A

AU - Liu, T. T.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Mitochondrial dynamics, fission and fusion, were first identified in yeast with investigation in heart cells beginning only in the last 5 to 7 years. In the ensuing time, it has become evident that these processes are not only required for healthy mitochondria, but also, that derangement of these processes contributes to disease. The fission and fusion proteins have a number of functions beyond the mitochondrial dynamics. Many of these functions are related to their membrane activities, such as apoptosis. However, other functions involve other areas of the mitochondria, such as OPA1's role in maintaining cristae structure and preventing cytochrome c leak, and its essential (at least a 10 kDa fragment of OPA1) role in mtDNA replication. In heart disease, changes in expression of these important proteins can have detrimental effects on mitochondrial and cellular function.

AB - Mitochondrial dynamics, fission and fusion, were first identified in yeast with investigation in heart cells beginning only in the last 5 to 7 years. In the ensuing time, it has become evident that these processes are not only required for healthy mitochondria, but also, that derangement of these processes contributes to disease. The fission and fusion proteins have a number of functions beyond the mitochondrial dynamics. Many of these functions are related to their membrane activities, such as apoptosis. However, other functions involve other areas of the mitochondria, such as OPA1's role in maintaining cristae structure and preventing cytochrome c leak, and its essential (at least a 10 kDa fragment of OPA1) role in mtDNA replication. In heart disease, changes in expression of these important proteins can have detrimental effects on mitochondrial and cellular function.

UR - http://www.scopus.com/inward/record.url?scp=85007464373&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85007464373&partnerID=8YFLogxK

U2 - 10.1002/cphy.c150022

DO - 10.1002/cphy.c150022

M3 - Article

C2 - 26756641

AN - SCOPUS:85007464373

VL - 6

SP - 507

EP - 526

JO - Comprehensive Physiology

JF - Comprehensive Physiology

SN - 2040-4603

IS - 1

ER -