Mitochondrial dynamics and division in budding yeast

Janet M. Shaw, Jodi Nunnari

Research output: Contribution to journalArticle

278 Citations (Scopus)

Abstract

Mitochondria adopt a variety of different shapes in eukaryotic cells, ranging from multiple, small compartments to elaborate tubular networks. The establishment and maintenance of different mitochondrial morphologies depends, in part, on the equilibrium between opposing fission and fusion events. Recent studies in yeast, flies, worms and mammalian cells indicate that three high-molecular-weight GTPases control mitochondrial membrane dynamics. One of these is a dynamin-related GTPase that acts on the outer mitochondrial membrane to regulate fission. Recently, genetic approaches in budding yeast have identified additional components of the fission machinery. These and other new findings suggest a common mechanism for membrane fission events that has been conserved and adapted during eukaryotic evolution.

Original languageEnglish (US)
Pages (from-to)178-184
Number of pages7
JournalTrends in Cell Biology
Volume12
Issue number4
DOIs
StatePublished - Apr 1 2002

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Mitochondrial Dynamics
Saccharomycetales
GTP Phosphohydrolases
Mitochondrial Membranes
Dynamins
Eukaryotic Cells
Diptera
Mitochondria
Yeasts
Molecular Weight
Maintenance
Membranes

ASJC Scopus subject areas

  • Cell Biology

Cite this

Mitochondrial dynamics and division in budding yeast. / Shaw, Janet M.; Nunnari, Jodi.

In: Trends in Cell Biology, Vol. 12, No. 4, 01.04.2002, p. 178-184.

Research output: Contribution to journalArticle

Shaw, Janet M. ; Nunnari, Jodi. / Mitochondrial dynamics and division in budding yeast. In: Trends in Cell Biology. 2002 ; Vol. 12, No. 4. pp. 178-184.
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