TY - JOUR
T1 - Mitochondrial dynamics and division in budding yeast
AU - Shaw, Janet M.
AU - Nunnari, Jodi
PY - 2002/4/1
Y1 - 2002/4/1
N2 - Mitochondria adopt a variety of different shapes in eukaryotic cells, ranging from multiple, small compartments to elaborate tubular networks. The establishment and maintenance of different mitochondrial morphologies depends, in part, on the equilibrium between opposing fission and fusion events. Recent studies in yeast, flies, worms and mammalian cells indicate that three high-molecular-weight GTPases control mitochondrial membrane dynamics. One of these is a dynamin-related GTPase that acts on the outer mitochondrial membrane to regulate fission. Recently, genetic approaches in budding yeast have identified additional components of the fission machinery. These and other new findings suggest a common mechanism for membrane fission events that has been conserved and adapted during eukaryotic evolution.
AB - Mitochondria adopt a variety of different shapes in eukaryotic cells, ranging from multiple, small compartments to elaborate tubular networks. The establishment and maintenance of different mitochondrial morphologies depends, in part, on the equilibrium between opposing fission and fusion events. Recent studies in yeast, flies, worms and mammalian cells indicate that three high-molecular-weight GTPases control mitochondrial membrane dynamics. One of these is a dynamin-related GTPase that acts on the outer mitochondrial membrane to regulate fission. Recently, genetic approaches in budding yeast have identified additional components of the fission machinery. These and other new findings suggest a common mechanism for membrane fission events that has been conserved and adapted during eukaryotic evolution.
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U2 - 10.1016/S0962-8924(01)02246-2
DO - 10.1016/S0962-8924(01)02246-2
M3 - Article
C2 - 11978537
AN - SCOPUS:0036536714
VL - 12
SP - 178
EP - 184
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 4
ER -