Mitochondrial antigens as targets of cellular and humoral auto-immunity in primary biliary cirrhosis

Yasunori Ichiki, Carlo Selmi, Shinji Shimoda, Hiromi Ishibashi, Stuart C. Gordon, M. Eric Gershwin

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Several factors point toward an auto-immune pathogenesis for primary biliary cirrhosis (PBC), mostly based on the presence of serum auto-antibodies to mitochondrial antigens (AMAs) and autoreactive T cells (both helper and cytotoxic). Interestingly, epitopes recognized by AMA and T-cell clones are located within overlapping areas of the antigens. Moreover, a role for an imbalance in cytokine pattern and for natural-killer lymphocytes has also been proposed. Despite several experimental reports, no clear evidence is available regarding the interaction of these factors leading to bile duct destruction. This article reviews the current reports regarding the auto-immune reaction against mitochondrial auto-antigens in PBC.

Original languageEnglish (US)
Pages (from-to)83-91
Number of pages9
JournalClinical Reviews in Allergy and Immunology
Volume28
Issue number2
StatePublished - Apr 2005

Keywords

  • 2-oxo-acid dehydrogenase complex
  • Auto-antibody
  • Auto-epitope
  • Auto-immunity
  • Primary biliary cirrhosis
  • Pyruvate dehydrogenase complex

ASJC Scopus subject areas

  • Immunology and Allergy

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