Mitochondria: In sickness and in health

Jodi Nunnari, Anu Suomalainen

Research output: Contribution to journalArticle

1140 Scopus citations

Abstract

Mitochondria perform diverse yet interconnected functions, producing ATP and many biosynthetic intermediates while also contributing to cellular stress responses such as autophagy and apoptosis. Mitochondria form a dynamic, interconnected network that is intimately integrated with other cellular compartments. In addition, mitochondrial functions extend beyond the boundaries of the cell and influence an organism's physiology by regulating communication between cells and tissues. It is therefore not surprising that mitochondrial dysfunction has emerged as a key factor in a myriad of diseases, including neurodegenerative and metabolic disorders. We provide a current view of how mitochondrial functions impinge on health and disease.

Original languageEnglish (US)
Pages (from-to)1145-1159
Number of pages15
JournalCell
Volume148
Issue number6
DOIs
StatePublished - Mar 16 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Nunnari, J., & Suomalainen, A. (2012). Mitochondria: In sickness and in health. Cell, 148(6), 1145-1159. https://doi.org/10.1016/j.cell.2012.02.035