Miswiring of limbic thalamocortical projections in the absence of ephrin-A5

Daniela Uziel, Sven Mühlfriedel, Konstantinos Zarbalis, Wolfgang Wurst, Pat Levitt, Jürgen Bolz

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Axon guidance cues of the ephrin ligand family have been hypothesized to regulate the formation of thalamocortical connections, but in vivo evidence for such a role has not been examined directly. To test whether ephrin-mediated repulsive cues participate in sorting the projections originating from distinct thalamic nuclei, we analyzed the organization of somatosensory and anterior cingulate afferents postnatally in mice lacking ephrin-A5 gene expression. Projections from ventrobasal and laterodorsal nuclei to their respective sensory and limbic cortical areas developed normally. However, a portion of limbic thalamic neurons from the laterodorsal nucleus also formed additional projections to somatosensory cortical territories, thus maintaining inappropriate dual projections to multiple cortical regions. These results suggest that ephrin-A5 is not required for the formation of normal cortical projections from the appropriate thalamic nuclei, but rather acts as a guidance cue that restricts limbic thalamic axons from inappropriate neocortical regions.

Original languageEnglish (US)
Pages (from-to)9352-9357
Number of pages6
JournalJournal of Neuroscience
Issue number21
StatePublished - Nov 1 2002
Externally publishedYes


  • Axonal guidance
  • Cortical development
  • Ephrin
  • Limbic system
  • Thalamocortical circuits
  • Wiring molecules

ASJC Scopus subject areas

  • Neuroscience(all)


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