Neuronal plasticity depends on plasma membrane Ca2+ influx, resulting in activity-dependent gene transcription. Calmodulin (CaM) activated by Ca2+ initiates the nuclear events, but how CaM makes its way to the nucleus has remained elusive. Ma et al. now show that CaMKIIγ transports CaM from cell surface Ca2+ channels to the nucleus.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)