Mission CaMKIIγ: Shuttle calmodulin from membrane to nucleus

Zulfiqar A. Malik, Ivar S. Stein, Manuel F Navedo, Johannes W Hell

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Neuronal plasticity depends on plasma membrane Ca2+ influx, resulting in activity-dependent gene transcription. Calmodulin (CaM) activated by Ca2+ initiates the nuclear events, but how CaM makes its way to the nucleus has remained elusive. Ma et al. now show that CaMKIIγ transports CaM from cell surface Ca2+ channels to the nucleus.

Original languageEnglish (US)
Pages (from-to)235-237
Number of pages3
JournalCell
Volume159
Issue number2
DOIs
StatePublished - Oct 9 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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