Misoprostol for treatment of early pregnancy failure in women with previous uterine surgery

Beatrice A. Chen, Matthew F. Reeves, Mitchell D Creinin, Jerry M. Gilles, Kurt Barnhart, Carolyn Westhoff, Jun Zhang

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Objective: Misoprostol use in early pregnancy may incur a risk of uterine rupture in women with previous uterine surgery. Study Design: We analyzed 488 women who received misoprostol 800 μg vaginally in a study that evaluated medical and surgical management of early pregnancy failure. Subjects received a repeat misoprostol dose if expulsion was not confirmed 2 days after treatment. We compared efficacy, acceptability, and safety in subjects with a history (n = 78 women) or absence (n = 410 women) of uterine surgery, defined as cesarean delivery or myomectomy. Results: Expulsion rates after a single misoprostol dose (69% vs 72%; P = .64) and overall success at 30 days (82% vs 85%; P = .50) were comparable. Pain, bleeding, complications, and acceptability did not differ. No uterine ruptures occurred (95% CI, 0, 3.8%). Conclusion: Misoprostol treatment for early pregnancy failure had similar success, acceptability, and complications in women with and without previous uterine surgery.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Issue number6
StatePublished - Jun 2008
Externally publishedYes


  • cesarean delivery
  • early pregnancy failure
  • miscarriage
  • misoprostol
  • myomectomy

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology


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