Misonidazole as a chemosensitizer in the treatment of the dunning prostage cancer model

Ralph W deVere White, N. A. Romas, P. Tomashefsky, E. J. Hall, C. A. Olsson

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Utilizing a Dunning prostate tumor model, we investigated the ability of misonidazole, a compound with known radiosensitizing properties, to act as a chemosensitizer when administered in combination with the alkylating agent cyclophosphamide. This combination caused a decrease in tumor growth rate when compared to the growth of the tumor in animals receiving cyclophosphamide alone. However, only at toxic levels was this decrease statistically significant (p < 0.01).

Original languageEnglish (US)
Pages (from-to)374-377
Number of pages4
JournalJournal of Urology
Volume131
Issue number2
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Urology

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    deVere White, R. W., Romas, N. A., Tomashefsky, P., Hall, E. J., & Olsson, C. A. (1984). Misonidazole as a chemosensitizer in the treatment of the dunning prostage cancer model. Journal of Urology, 131(2), 374-377.