Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

Dawn M. Dudley, Koen K. van Rompay, Lark L Schneider, Amir Ardeshir, Rebekah I. Keesler, Eliza Bliss-Moreau, Peta L. Grigsby, Rosemary J. Steinbach, Alec J. Hirsch, Rhonda P. MacAllister, Heidi L. Pecoraro, Lois M. Colgin, Travis Hodge, Daniel N. Streblow, Suzette Tardif, Jean L. Patterson, Manasi Tamhankar, Maxim Seferovic, Kjersti M. Aagaard, Claudia Sánchez San MartínCharles Y. Chiu, Antonito T. Panganiban, Ronald S. Veazey, Xiaolei Wang, Nicholas J. Maness, Margaret H. Gilbert, Rudolf P. Bohm, Kristina M. Adams Waldorf, Michael Gale, Lakshmi Rajagopal, Charlotte E. Hotchkiss, Emma L. Mohr, Saverio V. Capuano, Heather A. Simmons, Andres Mejia, Thomas C. Friedrich, Thaddeus G. Golos, David H. O’Connor

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalNature Medicine
DOIs
StateAccepted/In press - Jul 2 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Dudley, D. M., van Rompay, K. K., Schneider, L. L., Ardeshir, A., Keesler, R. I., Bliss-Moreau, E., Grigsby, P. L., Steinbach, R. J., Hirsch, A. J., MacAllister, R. P., Pecoraro, H. L., Colgin, L. M., Hodge, T., Streblow, D. N., Tardif, S., Patterson, J. L., Tamhankar, M., Seferovic, M., Aagaard, K. M., ... O’Connor, D. H. (Accepted/In press). Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. Nature Medicine, 1-4. https://doi.org/10.1038/s41591-018-0088-5