MiR-96 downregulates RECK to promote growth and motility of non-small cell lung cancer cells

Haizhou Guo; Qianping Li; Weihao Li; Tianliang Zheng; Song Zhao; Zhangsuo Liu

doi:10.1007/s11010-014-1966-x

MiR-96 downregulates RECK to promote growth and motility of non-small cell lung cancer cells

Haizhou Guo, Qianping Li, Weihao Li, Tianliang Zheng, Song Zhao, Zhangsuo Liu

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

MicroRNAs play critical roles in the development and progression of non-small cell lung cancer (NSCLC). miR-96 acts as an oncogene in some malignancies, while its role in NSCLC is unclear. Here, we validated that miR-96 was significantly increased in both human NSCLC tissues and cell lines. Inhibition of miR-96 expression remarkably reduced cell proliferation, colony formation, migration, and invasion of NSCLC cells. Reversion-inducing-cysteine- rich protein with kazal motifs (RECK) was identified as a target of miR-96 in NSCLC cells. In addition, the expression of RECK was found to be negatively correlated with the expression of miR-96 in NSCLC tissues. Our data suggest that miR-96 might promote the growth and motility of NSCLC cells partially by targeting RECK.

Original language	English (US)
Pages (from-to)	155-160
Number of pages	6
Journal	Molecular and Cellular Biochemistry
Volume	390
Issue number	1-2
DOIs	https://doi.org/10.1007/s11010-014-1966-x
State	Published - Jan 1 2014
Externally published	Yes

Keywords

Growth
Invasion
Migration
miR-96
Non-small cell lung cancer
RECK

ASJC Scopus subject areas

Molecular Biology
Clinical Biochemistry
Cell Biology

Access to Document

10.1007/s11010-014-1966-x

Fingerprint Dive into the research topics of 'MiR-96 downregulates RECK to promote growth and motility of non-small cell lung cancer cells'. Together they form a unique fingerprint.

Cite this

@article{6be0c4d6830f4f2b821afaf640fa03bf,

title = "MiR-96 downregulates RECK to promote growth and motility of non-small cell lung cancer cells",

abstract = "MicroRNAs play critical roles in the development and progression of non-small cell lung cancer (NSCLC). miR-96 acts as an oncogene in some malignancies, while its role in NSCLC is unclear. Here, we validated that miR-96 was significantly increased in both human NSCLC tissues and cell lines. Inhibition of miR-96 expression remarkably reduced cell proliferation, colony formation, migration, and invasion of NSCLC cells. Reversion-inducing-cysteine- rich protein with kazal motifs (RECK) was identified as a target of miR-96 in NSCLC cells. In addition, the expression of RECK was found to be negatively correlated with the expression of miR-96 in NSCLC tissues. Our data suggest that miR-96 might promote the growth and motility of NSCLC cells partially by targeting RECK.",

keywords = "Growth, Invasion, Migration, miR-96, Non-small cell lung cancer, RECK",

author = "Haizhou Guo and Qianping Li and Weihao Li and Tianliang Zheng and Song Zhao and Zhangsuo Liu",

year = "2014",

month = jan,

day = "1",

doi = "10.1007/s11010-014-1966-x",

language = "English (US)",

volume = "390",

pages = "155--160",

journal = "Molecular and Cellular Biochemistry",

issn = "0300-8177",

publisher = "Springer Netherlands",

number = "1-2",

}

TY - JOUR

T1 - MiR-96 downregulates RECK to promote growth and motility of non-small cell lung cancer cells

AU - Guo, Haizhou

AU - Li, Qianping

AU - Li, Weihao

AU - Zheng, Tianliang

AU - Zhao, Song

AU - Liu, Zhangsuo

PY - 2014/1/1

Y1 - 2014/1/1

N2 - MicroRNAs play critical roles in the development and progression of non-small cell lung cancer (NSCLC). miR-96 acts as an oncogene in some malignancies, while its role in NSCLC is unclear. Here, we validated that miR-96 was significantly increased in both human NSCLC tissues and cell lines. Inhibition of miR-96 expression remarkably reduced cell proliferation, colony formation, migration, and invasion of NSCLC cells. Reversion-inducing-cysteine- rich protein with kazal motifs (RECK) was identified as a target of miR-96 in NSCLC cells. In addition, the expression of RECK was found to be negatively correlated with the expression of miR-96 in NSCLC tissues. Our data suggest that miR-96 might promote the growth and motility of NSCLC cells partially by targeting RECK.

AB - MicroRNAs play critical roles in the development and progression of non-small cell lung cancer (NSCLC). miR-96 acts as an oncogene in some malignancies, while its role in NSCLC is unclear. Here, we validated that miR-96 was significantly increased in both human NSCLC tissues and cell lines. Inhibition of miR-96 expression remarkably reduced cell proliferation, colony formation, migration, and invasion of NSCLC cells. Reversion-inducing-cysteine- rich protein with kazal motifs (RECK) was identified as a target of miR-96 in NSCLC cells. In addition, the expression of RECK was found to be negatively correlated with the expression of miR-96 in NSCLC tissues. Our data suggest that miR-96 might promote the growth and motility of NSCLC cells partially by targeting RECK.

KW - Growth

KW - Invasion

KW - Migration

KW - miR-96

KW - Non-small cell lung cancer

KW - RECK

UR - http://www.scopus.com/inward/record.url?scp=84898910219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898910219&partnerID=8YFLogxK

U2 - 10.1007/s11010-014-1966-x

DO - 10.1007/s11010-014-1966-x

M3 - Article

C2 - 24469470

AN - SCOPUS:84898910219

VL - 390

SP - 155

EP - 160

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

SN - 0300-8177

IS - 1-2

ER -