Abstract
MicroRNAs play critical roles in the development and progression of non-small cell lung cancer (NSCLC). miR-96 acts as an oncogene in some malignancies, while its role in NSCLC is unclear. Here, we validated that miR-96 was significantly increased in both human NSCLC tissues and cell lines. Inhibition of miR-96 expression remarkably reduced cell proliferation, colony formation, migration, and invasion of NSCLC cells. Reversion-inducing-cysteine- rich protein with kazal motifs (RECK) was identified as a target of miR-96 in NSCLC cells. In addition, the expression of RECK was found to be negatively correlated with the expression of miR-96 in NSCLC tissues. Our data suggest that miR-96 might promote the growth and motility of NSCLC cells partially by targeting RECK.
Original language | English (US) |
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Pages (from-to) | 155-160 |
Number of pages | 6 |
Journal | Molecular and Cellular Biochemistry |
Volume | 390 |
Issue number | 1-2 |
DOIs | |
State | Published - Jan 1 2014 |
Externally published | Yes |
Keywords
- Growth
- Invasion
- Migration
- miR-96
- Non-small cell lung cancer
- RECK
ASJC Scopus subject areas
- Molecular Biology
- Clinical Biochemistry
- Cell Biology