MiR-96 downregulates RECK to promote growth and motility of non-small cell lung cancer cells

Haizhou Guo, Qianping Li, Weihao Li, Tianliang Zheng, Song Zhao, Zhangsuo Liu

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

MicroRNAs play critical roles in the development and progression of non-small cell lung cancer (NSCLC). miR-96 acts as an oncogene in some malignancies, while its role in NSCLC is unclear. Here, we validated that miR-96 was significantly increased in both human NSCLC tissues and cell lines. Inhibition of miR-96 expression remarkably reduced cell proliferation, colony formation, migration, and invasion of NSCLC cells. Reversion-inducing-cysteine- rich protein with kazal motifs (RECK) was identified as a target of miR-96 in NSCLC cells. In addition, the expression of RECK was found to be negatively correlated with the expression of miR-96 in NSCLC tissues. Our data suggest that miR-96 might promote the growth and motility of NSCLC cells partially by targeting RECK.

Original languageEnglish (US)
Pages (from-to)155-160
Number of pages6
JournalMolecular and Cellular Biochemistry
Volume390
Issue number1-2
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Growth
  • Invasion
  • Migration
  • miR-96
  • Non-small cell lung cancer
  • RECK

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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