MiR-146a and miR-155 delineate a microRNA fingerprint associated with toxoplasma persistence in the host brain

Dominique Cannella, Marie Pierre Brenier-Pinchart, Laurence Braun, Jason M. vanRooyen, Alexandre Bougdour, Olivier Bastien, Michael S. Behnke, Rose Laurence Curt, Aurélie Curt, Jeroen Saeij, L. David Sibley, Hervé Pelloux, Mohamed Ali Hakimi

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

microRNAs were recently found to be regulators of the host response to infection by apicomplexan parasites. In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that werecoinduced in the brains of mice challenged with Toxoplasma in a strain-specific manner. These microRNAs define a characteristic fingerprint for infection by type II strains, which are the most prevalent cause of human toxoplasmosis in Europe and North America. Using forward genetics, we showed that strain-specific differences in miR-146a modulation were in part mediated by the rhoptry kinase, ROP16. Remarkably, we found that miR-146a deficiency led to better control of parasite burden in the gut and most likely of early parasite dissemination in the brain tissue, resulting in the long-term survival of mice.

Original languageEnglish (US)
Pages (from-to)928-937
Number of pages10
JournalCell Reports
Volume6
Issue number5
DOIs
StatePublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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