Abstract
Ras homolog (Rho) family small GTPases are critical regulators of actin cytoskeletal organization, cell motility, proliferation, and survival. Surprisingly, the large majority of the studies underlying our knowledge of Rho protein function have been carried out in cultured cells, and it is only recently that researchers have begun to assess Rho GTPase regulation and function in vivo. The purpose of this review is to evaluate our current knowledge of Rho GTPase function in mouse mammary gland development, tumorigenesis and metastasis. Although our knowledge is still incomplete, these studies are already uncovering important themes as to the physiological roles of Rho GTPase signaling in normal mammary gland development and function. Essential contributions of Rho proteins to breast cancer initiation, tumor progression, and metastatic dissemination have also been identified.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 278-289 |
| Number of pages | 12 |
| Journal | Molecular Endocrinology |
| Volume | 30 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2016 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Biology
- Endocrinology
Cite this
Minireview : Mouse models of Rho GTPase function in mammary gland development, tumorigenesis, and metastasis. / Zuo, Yan; Oh, Wonkyung; Ulu, Arzu; Frost, Jeffrey A.
In: Molecular Endocrinology, Vol. 30, No. 3, 01.03.2016, p. 278-289.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Minireview
T2 - Mouse models of Rho GTPase function in mammary gland development, tumorigenesis, and metastasis
AU - Zuo, Yan
AU - Oh, Wonkyung
AU - Ulu, Arzu
AU - Frost, Jeffrey A.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Ras homolog (Rho) family small GTPases are critical regulators of actin cytoskeletal organization, cell motility, proliferation, and survival. Surprisingly, the large majority of the studies underlying our knowledge of Rho protein function have been carried out in cultured cells, and it is only recently that researchers have begun to assess Rho GTPase regulation and function in vivo. The purpose of this review is to evaluate our current knowledge of Rho GTPase function in mouse mammary gland development, tumorigenesis and metastasis. Although our knowledge is still incomplete, these studies are already uncovering important themes as to the physiological roles of Rho GTPase signaling in normal mammary gland development and function. Essential contributions of Rho proteins to breast cancer initiation, tumor progression, and metastatic dissemination have also been identified.
AB - Ras homolog (Rho) family small GTPases are critical regulators of actin cytoskeletal organization, cell motility, proliferation, and survival. Surprisingly, the large majority of the studies underlying our knowledge of Rho protein function have been carried out in cultured cells, and it is only recently that researchers have begun to assess Rho GTPase regulation and function in vivo. The purpose of this review is to evaluate our current knowledge of Rho GTPase function in mouse mammary gland development, tumorigenesis and metastasis. Although our knowledge is still incomplete, these studies are already uncovering important themes as to the physiological roles of Rho GTPase signaling in normal mammary gland development and function. Essential contributions of Rho proteins to breast cancer initiation, tumor progression, and metastatic dissemination have also been identified.
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UR - http://www.scopus.com/inward/citedby.url?scp=84959566382&partnerID=8YFLogxK
U2 - 10.1210/me.2015-1294
DO - 10.1210/me.2015-1294
M3 - Review article
C2 - 26677753
AN - SCOPUS:84959566382
VL - 30
SP - 278
EP - 289
JO - Molecular Endocrinology
JF - Molecular Endocrinology
SN - 0888-8809
IS - 3
ER -