Minireview: Mouse models of Rho GTPase function in mammary gland development, tumorigenesis, and metastasis

Yan Zuo, Wonkyung Oh, Arzu Ulu, Jeffrey A. Frost

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Ras homolog (Rho) family small GTPases are critical regulators of actin cytoskeletal organization, cell motility, proliferation, and survival. Surprisingly, the large majority of the studies underlying our knowledge of Rho protein function have been carried out in cultured cells, and it is only recently that researchers have begun to assess Rho GTPase regulation and function in vivo. The purpose of this review is to evaluate our current knowledge of Rho GTPase function in mouse mammary gland development, tumorigenesis and metastasis. Although our knowledge is still incomplete, these studies are already uncovering important themes as to the physiological roles of Rho GTPase signaling in normal mammary gland development and function. Essential contributions of Rho proteins to breast cancer initiation, tumor progression, and metastatic dissemination have also been identified.

Original languageEnglish (US)
Pages (from-to)278-289
Number of pages12
JournalMolecular Endocrinology
Volume30
Issue number3
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

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