Minimum inhibitory concentrations of selected antimicrobial agents for moraxella bovoculi associated with infectious bovine keratoconjunctivitis

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Infectious bovine keratoconjunctivitis (IBK) has been associated with ocular infections by Moraxella bovis, the established etiologic agent of IBK, and more recently, Moraxella bovoculi, a recently described species of Moraxella. To assist in designing rational treatment regimens for M. bovoculi infections associated with IBK, the in vitro susceptibilities of 57 M. bovoculi field isolates cultured from eyes of cattle with IBK in California from 2002 through 2007 were determined. The minimum inhibitory concentration required to inhibit the growth of 90% of organisms (MIC 90) of the following 18 antibiotics tested in the present study were: danofloxacin and enrofloxacin: ≤0.12 μg/ml; ampicillin and ceftiofur: ≤0.25 μg/ ml; penicillin: 0.25 μg/ml; gentamicin: ≤1 μg/ml; chlortetracycline, oxytetracycline, and tiamulin: 1 μg/ml; florfenicol: 0.5 μg/ ml; trimethoprim-sulfamethoxazole: ≤2/38 μg/ml; clindamycin: 2 μg/ml; neomycin and tilmicosin: ≤4 μg/ml; tulathromycin: 4 μg/ml; spectinomycin and tylosin: 16 μg/ml; and sulfadimethoxine: >256 μg/ml. The low MIC 90 of these M. bovoculiisolates suggests that commonly used antibiotics for treatment of IBK associated with M. bovis should also be effective against M. bovoculi.

Original languageEnglish (US)
Pages (from-to)552-555
Number of pages4
JournalJournal of Veterinary Diagnostic Investigation
Volume23
Issue number3
DOIs
StatePublished - May 2011

Fingerprint

Infectious Keratoconjunctivitis
Moraxella
keratoconjunctivitis
Microbial Sensitivity Tests
minimum inhibitory concentration
Anti-Infective Agents
anti-infective agents
cattle
Moraxella (Moraxella) bovis
Moraxella bovis
Sulfadimethoxine
eyes
antibiotics
Tylosin
danofloxacin
sulfadimethoxine
Spectinomycin
tiamulin
Anti-Bacterial Agents
Eye Infections

Keywords

  • Infectious bovine keratoconjunctivitis
  • Minimum inhibitory concentration
  • Moraxella bovis
  • Moraxella bovoculi

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{8e43e3da7db4430ebb5e8745b99f0431,
title = "Minimum inhibitory concentrations of selected antimicrobial agents for moraxella bovoculi associated with infectious bovine keratoconjunctivitis",
abstract = "Infectious bovine keratoconjunctivitis (IBK) has been associated with ocular infections by Moraxella bovis, the established etiologic agent of IBK, and more recently, Moraxella bovoculi, a recently described species of Moraxella. To assist in designing rational treatment regimens for M. bovoculi infections associated with IBK, the in vitro susceptibilities of 57 M. bovoculi field isolates cultured from eyes of cattle with IBK in California from 2002 through 2007 were determined. The minimum inhibitory concentration required to inhibit the growth of 90{\%} of organisms (MIC 90) of the following 18 antibiotics tested in the present study were: danofloxacin and enrofloxacin: ≤0.12 μg/ml; ampicillin and ceftiofur: ≤0.25 μg/ ml; penicillin: 0.25 μg/ml; gentamicin: ≤1 μg/ml; chlortetracycline, oxytetracycline, and tiamulin: 1 μg/ml; florfenicol: 0.5 μg/ ml; trimethoprim-sulfamethoxazole: ≤2/38 μg/ml; clindamycin: 2 μg/ml; neomycin and tilmicosin: ≤4 μg/ml; tulathromycin: 4 μg/ml; spectinomycin and tylosin: 16 μg/ml; and sulfadimethoxine: >256 μg/ml. The low MIC 90 of these M. bovoculiisolates suggests that commonly used antibiotics for treatment of IBK associated with M. bovis should also be effective against M. bovoculi.",
keywords = "Infectious bovine keratoconjunctivitis, Minimum inhibitory concentration, Moraxella bovis, Moraxella bovoculi",
author = "Angelos, {John A} and Ball, {Louise M.} and Byrne, {Barbara A}",
year = "2011",
month = "5",
doi = "10.1177/1040638711404154",
language = "English (US)",
volume = "23",
pages = "552--555",
journal = "Journal of Veterinary Diagnostic Investigation",
issn = "1040-6387",
publisher = "American Association of Veterinary Laboratory Diagnosticians",
number = "3",

}

TY - JOUR

T1 - Minimum inhibitory concentrations of selected antimicrobial agents for moraxella bovoculi associated with infectious bovine keratoconjunctivitis

AU - Angelos, John A

AU - Ball, Louise M.

AU - Byrne, Barbara A

PY - 2011/5

Y1 - 2011/5

N2 - Infectious bovine keratoconjunctivitis (IBK) has been associated with ocular infections by Moraxella bovis, the established etiologic agent of IBK, and more recently, Moraxella bovoculi, a recently described species of Moraxella. To assist in designing rational treatment regimens for M. bovoculi infections associated with IBK, the in vitro susceptibilities of 57 M. bovoculi field isolates cultured from eyes of cattle with IBK in California from 2002 through 2007 were determined. The minimum inhibitory concentration required to inhibit the growth of 90% of organisms (MIC 90) of the following 18 antibiotics tested in the present study were: danofloxacin and enrofloxacin: ≤0.12 μg/ml; ampicillin and ceftiofur: ≤0.25 μg/ ml; penicillin: 0.25 μg/ml; gentamicin: ≤1 μg/ml; chlortetracycline, oxytetracycline, and tiamulin: 1 μg/ml; florfenicol: 0.5 μg/ ml; trimethoprim-sulfamethoxazole: ≤2/38 μg/ml; clindamycin: 2 μg/ml; neomycin and tilmicosin: ≤4 μg/ml; tulathromycin: 4 μg/ml; spectinomycin and tylosin: 16 μg/ml; and sulfadimethoxine: >256 μg/ml. The low MIC 90 of these M. bovoculiisolates suggests that commonly used antibiotics for treatment of IBK associated with M. bovis should also be effective against M. bovoculi.

AB - Infectious bovine keratoconjunctivitis (IBK) has been associated with ocular infections by Moraxella bovis, the established etiologic agent of IBK, and more recently, Moraxella bovoculi, a recently described species of Moraxella. To assist in designing rational treatment regimens for M. bovoculi infections associated with IBK, the in vitro susceptibilities of 57 M. bovoculi field isolates cultured from eyes of cattle with IBK in California from 2002 through 2007 were determined. The minimum inhibitory concentration required to inhibit the growth of 90% of organisms (MIC 90) of the following 18 antibiotics tested in the present study were: danofloxacin and enrofloxacin: ≤0.12 μg/ml; ampicillin and ceftiofur: ≤0.25 μg/ ml; penicillin: 0.25 μg/ml; gentamicin: ≤1 μg/ml; chlortetracycline, oxytetracycline, and tiamulin: 1 μg/ml; florfenicol: 0.5 μg/ ml; trimethoprim-sulfamethoxazole: ≤2/38 μg/ml; clindamycin: 2 μg/ml; neomycin and tilmicosin: ≤4 μg/ml; tulathromycin: 4 μg/ml; spectinomycin and tylosin: 16 μg/ml; and sulfadimethoxine: >256 μg/ml. The low MIC 90 of these M. bovoculiisolates suggests that commonly used antibiotics for treatment of IBK associated with M. bovis should also be effective against M. bovoculi.

KW - Infectious bovine keratoconjunctivitis

KW - Minimum inhibitory concentration

KW - Moraxella bovis

KW - Moraxella bovoculi

UR - http://www.scopus.com/inward/record.url?scp=79957673619&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79957673619&partnerID=8YFLogxK

U2 - 10.1177/1040638711404154

DO - 10.1177/1040638711404154

M3 - Article

VL - 23

SP - 552

EP - 555

JO - Journal of Veterinary Diagnostic Investigation

JF - Journal of Veterinary Diagnostic Investigation

SN - 1040-6387

IS - 3

ER -