Minimally Invasive coronary surgery compared to STernotomy coronary artery bypass grafting: The MIST trial

Ming Hao Guo, George A. Wells, David Glineur, Jacqueline Fortier, Piroze M. Davierwala, Keita Kikuchi, Massimo G. Lemma, Yugal K. Mishra, Joseph McGinn, Mahesh Ramchandani, Prem Rabindra, Sathyaki Nambala, Kuan Ming Chiu, Bob Kiaii, Sarah Gibson, Marc Ruel

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Rationale: Minimally invasive cardiac surgery has emerged as a safe alternative to standard cardiac surgery. Minimally invasive coronary surgery (MICS CABG) was developed to allow adequate exposure and complete revascularization in CABG from a small thoracotomy incision without cardiopulmonary bypass. Multiple studies have reported significant shorter length of hospital stay and earlier postoperative physical recovery for MICS CABG patients when compared to sternotomy CABG patients. However, there have been no convincing clinical trials that demonstrate improvement in post-operative quality of life for patients who undergo MICS CABG. Study design: The Minimally Invasive Coronary Surgery compared to Sternotomy Coronary Artery Bypass Grafting (MIST) trial is a multi-centered, prospective randomized controlled trial that compares the quality of life and recovery in the early post-operative period between patients undergoing MICS CABG versus patients undergoing sternotomy CABG. Patients will be randomized either to the MICS CABG group or the sternotomy CABG group, and the target enrollment is 88 patients per group. The primary outcome is quality of life assessment performed by SF-36 questionnaire at 1 month. Conclusion: The MIST trial is the first prospective study that compares the quality of life between MICS CABG and sternotomy CABG patients. The results of this trial may enhance the procedural desirability of MICS CABG by patients and provide an incentive for surgeons and institutions to increase the availability of MICS CABG in suitable patients.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalContemporary Clinical Trials
StatePublished - Mar 2019
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)


Dive into the research topics of 'Minimally Invasive coronary surgery compared to STernotomy coronary artery bypass grafting: The MIST trial'. Together they form a unique fingerprint.

Cite this